Epigenetic Control of Immunity

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2014 Jun 4

PMID 24890513

Citations 75

Authors

Meinrad Busslinger

Alexander Tarakhovsky

Affiliations

Soon will be listed here.

Abstract

Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen receptor repertoire that matches the vast diversity of pathogens. In the innate immune system, the cell's heterogeneity and phenotypic plasticity enable flexible responses to changes in tissue homeostasis caused by infection or damage. The immune responses are calibrated by the graded activity of immune cells that can vary from yeast-like proliferation to lifetime dormancy. This article describes key epigenetic processes that contribute to the function of immune cells during health and disease.

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References

Cobaleda C, Jochum W, Busslinger M . Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature. 2007; 449(7161):473-7. DOI: 10.1038/nature06159. View

Smale S . Selective transcription in response to an inflammatory stimulus. Cell. 2010; 140(6):833-44. PMC: 2847629. DOI: 10.1016/j.cell.2010.01.037. View

Hadjur S, Williams L, Ryan N, Cobb B, Sexton T, Fraser P . Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature. 2009; 460(7253):410-3. PMC: 2869028. DOI: 10.1038/nature08079. View

Foster S, Hargreaves D, Medzhitov R . Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007; 447(7147):972-8. DOI: 10.1038/nature05836. View

Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield V . hDOT1L links histone methylation to leukemogenesis. Cell. 2005; 121(2):167-78. DOI: 10.1016/j.cell.2005.02.020. View

Lee J, Lee J, Kim H, Kim K, Park H, Kim J . EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012; 48(4):572-86. DOI: 10.1016/j.molcel.2012.09.004. View

Su I, Basavaraj A, Krutchinsky A, Hobert O, Ullrich A, Chait B . Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol. 2002; 4(2):124-31. DOI: 10.1038/ni876. View

Eldar A, Elowitz M . Functional roles for noise in genetic circuits. Nature. 2010; 467(7312):167-73. PMC: 4100692. DOI: 10.1038/nature09326. View

Guenther M, Lawton L, Rozovskaia T, Frampton G, Levine S, L Volkert T . Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes Dev. 2009; 22(24):3403-8. PMC: 2607073. DOI: 10.1101/gad.1741408. View

10.

Guo C, Yoon H, Franklin A, Jain S, Ebert A, Cheng H . CTCF-binding elements mediate control of V(D)J recombination. Nature. 2011; 477(7365):424-30. PMC: 3342812. DOI: 10.1038/nature10495. View

11.

Smith E, Shilatifard A . The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell. 2010; 40(5):689-701. PMC: 3037032. DOI: 10.1016/j.molcel.2010.11.031. View

12.

Perlot T, Alt F . Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol. 2009; 99:1-32. PMC: 3115588. DOI: 10.1016/S0065-2776(08)00601-9. View

13.

Sampath S, Marazzi I, Yap K, Sampath S, Krutchinsky A, Mecklenbrauker I . Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell. 2007; 27(4):596-608. DOI: 10.1016/j.molcel.2007.06.026. View

14.

Phillips J, Corces V . CTCF: master weaver of the genome. Cell. 2009; 137(7):1194-211. PMC: 3040116. DOI: 10.1016/j.cell.2009.06.001. View

15.

Schlimgen R, Reddy K, Singh H, Krangel M . Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. Nat Immunol. 2008; 9(7):802-9. PMC: 2561338. DOI: 10.1038/ni.1624. View

16.

Gilchrist M, Thorsson V, Li B, Rust A, Korb M, Roach J . Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature. 2006; 441(7090):173-8. DOI: 10.1038/nature04768. View

17.

Roldan E, Fuxa M, Chong W, Martinez D, Novatchkova M, Busslinger M . Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol. 2004; 6(1):31-41. PMC: 1592471. DOI: 10.1038/ni1150. View

18.

Gilchrist D, Adelman K . Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription. Biochim Biophys Acta. 2012; 1819(7):700-6. PMC: 3371112. DOI: 10.1016/j.bbagrm.2012.02.015. View

19.

Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P . Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 2009; 11(2):171-9. PMC: 2956121. DOI: 10.1038/ni.1827. View

20.

Deniaud E, Bickmore W . Transcription and the nuclear periphery: edge of darkness?. Curr Opin Genet Dev. 2009; 19(2):187-91. DOI: 10.1016/j.gde.2009.01.005. View