A Review on Regulation of DNA Methylation During Post-myocardial Infarction

Overview

Journal Front Pharmacol

Date 2024 Feb 28

PMID 38414735

Authors

Wenqiang Han

Wenxin Wang

Qinhong Wang

Kellina Maduray

Li Hao

Jingquan Zhong

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction (MI) imposes a huge medical and economic burden on society, and cardiac repair after MI involves a complex series of processes. Understanding the key mechanisms (such as apoptosis, autophagy, inflammation, and fibrosis) will facilitate further drug development and patient treatment. Presently, a substantial body of evidence suggests that the regulation of epigenetic processes contributes to cardiac repair following MI, with DNA methylation being among the notable epigenetic factors involved. This article will review the research on the mechanism of DNA methylation regulation after MI to provide some insights for future research and development of related drugs.

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