Meinrad Busslinger
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Explore the profile of Meinrad Busslinger including associated specialties, affiliations and a list of published articles.
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117
Citations
10322
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Recent Articles
1.
Fedl A, Tagoh H, Gruenbacher S, Sun Q, Schenk R, Froussios K, et al.
Nat Immunol
. 2024 Aug;
25(9):1663-1677.
PMID: 39179932
Early B cell lymphopoiesis depends on E2A, Ebf1, Pax5 and Ikaros family members. In the present study, we used acute protein degradation in mice to identify direct target genes of...
2.
Mandlbauer A, Sun Q, Popitsch N, Schwickert T, Spanova M, Wang J, et al.
EMBO J
. 2024 Apr;
43(12):2506-2525.
PMID: 38689024
Many microRNAs (miRNAs) are expressed with high spatiotemporal specificity during organismal development, with some being limited to rare cell types, often embedded in complex tissues. Yet, most miRNA profiling efforts...
3.
Gruenbacher S, Jaritz M, Hill L, Schafer M, Busslinger M
J Exp Med
. 2023 Sep;
220(12).
PMID: 37725138
The B cell regulator Pax5 consists of multiple domains whose function we analyzed in vivo by deletion in Pax5. While B lymphopoiesis was minimally affected in mice with homozygous deletion...
4.
Hill L, Jaritz M, Tagoh H, Schindler K, Kostanova-Poliakova D, Sun Q, et al.
EMBO J
. 2023 Jun;
42(15):e112741.
PMID: 37337907
While extended loop extrusion across the entire Igh locus controls V -DJ recombination, local regulatory sequences, such as the PAIR elements, may also activate V gene recombination in pro-B-cells. Here,...
5.
Hill L, Wutz G, Jaritz M, Tagoh H, Calderon L, Peters J, et al.
Nat Commun
. 2023 Apr;
14(1):2316.
PMID: 37085514
Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates V-DJ recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of...
6.
Wohner M, Pinter T, Bonelt P, Hagelkruys A, Kostanova-Poliakova D, Stadlmann J, et al.
Front Immunol
. 2023 Jan;
13:859598.
PMID: 36618345
Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the...
7.
Kaiser F, Gruenbacher S, Oyaga M, Nio E, Jaritz M, Sun Q, et al.
J Exp Med
. 2022 Dec;
220(1).
PMID: 36480208
No abstract available.
8.
Pinter T, Fischer M, Schafer M, Fellner M, Jude J, Zuber J, et al.
Front Immunol
. 2022 Oct;
13:979606.
PMID: 36189249
Plasma cells (PCs) and their progenitors plasmablasts (PBs) are essential for the acute and long-term protection of the host against infections by providing vast levels of highly specific antibodies. Several...
9.
Kaiser F, Gruenbacher S, Oyaga M, Nio E, Jaritz M, Sun Q, et al.
J Exp Med
. 2022 Aug;
219(9).
PMID: 35947077
The genetic causes of primary antibody deficiencies and autism spectrum disorder (ASD) are largely unknown. Here, we report a patient with hypogammaglobulinemia and ASD who carries biallelic mutations in the...
10.
Jurado S, Fedl A, Jaritz M, Kostanova-Poliakova D, Malin S, Mullighan C, et al.
EMBO J
. 2022 Feb;
41(7):e108397.
PMID: 35156727
While PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia (B-ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion proteins. PAX5-JAK2 encodes a...