Human IL-25- and IL-33-responsive Type 2 Innate Lymphoid Cells Are Defined by Expression of CRTH2 and CD161

Overview

Journal Nat Immunol

Date 2011 Sep 13

PMID 21909091

Citations 585

Authors

Jenny M Mjosberg

Sara Trifari

Natasha K Crellin

Charlotte P Peters

Cornelis M Van Drunen

Berber Piet

Wytske J Fokkens

Tom Cupedo

Hergen Spits

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor RORγt, express CD127 (IL-7 receptor α-chain) and the natural killer cell marker CD161. Here we describe another lineage-negative CD127(+)CD161(+) ILC population found in humans that expressed the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2(+) ILCs were present in fetal and adult lung and gut. In fetal gut, these cells expressed IL-13 but not IL-17 or IL-22. There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines.

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