Early Development of Innate Lymphoid Cells

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2022 Nov 14

PMID 36374450

Authors

Yi Ding

Christelle Harly

Arundhoti Das

Avinash Bhandoola

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors and discuss possible mechanisms that separate ILCs from T cells. We consider mechanisms of lineage specification in early ILC development and also examine whether differences exist between adult and fetal ILC development.

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