» Articles » PMID: 23229471

Vitamin D: Do We Get Enough? A Discussion Between Vitamin D Experts in Order to Make a Step Towards the Harmonisation of Dietary Reference Intakes for Vitamin D Across Europe

Abstract

Unlabelled: On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized.

Introduction: Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive.

Methods: To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized.

Results: Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population.

Conclusion: To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.

Citing Articles

Vitamin D and cardiovascular diseases: A narrative review.

Alissa E J Family Med Prim Care. 2024; 13(4):1191-1199.

PMID: 38827691 PMC: 11141959. DOI: 10.4103/jfmpc.jfmpc_1481_23.


U-Shaped Association of Standardized Serum 25-Hydroxyvitamin D with Risk of Low Muscle Mass: A Population-Based Cross-Sectional Study.

Zhang G, Wang X, Tong M, Chen J, Ji Q J Multidiscip Healthc. 2023; 16:2167-2177.

PMID: 37547808 PMC: 10402717. DOI: 10.2147/JMDH.S420963.


Vitamin D in Neurological Diseases.

Plantone D, Primiano G, Manco C, Locci S, Servidei S, De Stefano N Int J Mol Sci. 2023; 24(1).

PMID: 36613531 PMC: 9820561. DOI: 10.3390/ijms24010087.


Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction.

Matta Reddy A, Iqbal M, Chopra H, Urmi S, Junapudi S, Bibi S EXCLI J. 2022; 21:967-990.

PMID: 36110560 PMC: 9441677. DOI: 10.17179/excli2022-4935.


Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study.

Tang Y, Wei F, Yu M, Zhou H, Wang Y, Cui Z Sci Rep. 2022; 12(1):10408.

PMID: 35729194 PMC: 9213555. DOI: 10.1038/s41598-022-14548-5.


References
1.
LeBoff M, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J . Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA. 1999; 281(16):1505-11. DOI: 10.1001/jama.281.16.1505. View

2.
MacLaughlin J, Holick M . Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985; 76(4):1536-8. PMC: 424123. DOI: 10.1172/JCI112134. View

3.
Fleet J, DeSmet M, Johnson R, Li Y . Vitamin D and cancer: a review of molecular mechanisms. Biochem J. 2011; 441(1):61-76. PMC: 4572477. DOI: 10.1042/BJ20110744. View

4.
Sai A, Walters R, Fang X, Gallagher J . Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab. 2010; 96(3):E436-46. PMC: 3047227. DOI: 10.1210/jc.2010-1886. View

5.
Mitri J, Muraru M, Pittas A . Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr. 2011; 65(9):1005-15. PMC: 4066381. DOI: 10.1038/ejcn.2011.118. View