Vitamin D in Vascular Calcification: A Double-Edged Sword?
Overview
Affiliations
Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification. Therefore, more complex underlying processes involving physiochemical changes to mineral balance, vascular remodelling and perturbed hormonal responses such as parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) are likely to contribute to VC. In particular, VC resulting from modifications to calcium, phosphate and vitamin D homeostasis has been recently elucidated. Notably, deregulation of vitamin D metabolism, dietary calcium intake and renal mineral handling are associated with imbalances in systemic calcium and phosphate levels and endothelial cell dysfunction, which can modulate both bone and soft tissue calcification. This review addresses the current understanding of VC pathophysiology, with a focus on the pathogenic role of vitamin D that has provided new insights into the mechanisms of VC.
Risk factors for radial artery calcification in patients with and without uremia.
Hao J, Wang S, Chen T, Yuan B, Hao L BMC Nephrol. 2025; 26(1):18.
PMID: 39799338 PMC: 11724451. DOI: 10.1186/s12882-024-03940-0.
Vitamin D, C-Reactive Protein, and Increased Fall Risk: A Genetic Epidemiological Study.
Sutherland J, Zhou A, Hypponen E Nutrients. 2025; 17(1.
PMID: 39796472 PMC: 11722653. DOI: 10.3390/nu17010038.
Monitoring of microvascular calcification by time-resolved photoacoustic microscopy.
Ma H, Yu Y, Zhu Y, Wu H, Qiu H, Gu Y Photoacoustics. 2024; 41:100664.
PMID: 39654983 PMC: 11626619. DOI: 10.1016/j.pacs.2024.100664.
El Zouka Y, Sheta E, Abdelrazek Salama M, Selima E, Refaat R, Salaheldin Abdelhamid Ibrahim S Sci Rep. 2024; 14(1):21371.
PMID: 39266573 PMC: 11393063. DOI: 10.1038/s41598-024-70872-y.
Inflammation-associated ectopic mineralization.
Song J, Liu M, Ma Y, Wan Q, Li J, Diao X Fundam Res. 2024; 3(6):1025-1038.
PMID: 38933004 PMC: 11197766. DOI: 10.1016/j.fmre.2022.04.020.