Structure and Mechanisms of SF1 DNA Helicases

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2012 Nov 20

PMID 23161005

Citations 36

Authors

Kevin D Raney

Alicia K Byrd

Suja Aarattuthodiyil

Affiliations

Soon will be listed here.

Abstract

Superfamily I is a large and diverse group of monomeric and dimeric helicases defined by a set of conserved sequence motifs. Members of this class are involved in essential processes in both DNA and RNA metabolism in all organisms. In addition to conserved amino acid sequences, they also share a common structure containing two RecA-like motifs involved in ATP binding and hydrolysis and nucleic acid binding and unwinding. Unwinding is facilitated by a "pin" structure which serves to split the incoming duplex. This activity has been measured using both ensemble and single-molecule conditions. SF1 helicase activity is modulated through interactions with other proteins.

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