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Comparisons Between the Structures of HCV and Rep Helicases Reveal Structural Similarities Between SF1 and SF2 Super-families of Helicases

Overview
Journal Protein Sci
Specialty Biochemistry
Date 1998 Apr 16
PMID 9541392
Citations 45
Authors
S Korolev
N Yao
T M Lohman
P C Weber
G Waksman
Affiliations
Soon will be listed here.
Abstract

Three helicase structures have been determined recently: that of the DNA helicase PcrA, that of the hepatitis C virus RNA helicase, and that of the Escherichia coli DNA helicase Rep. PcrA and Rep belong to the same super-family of helicases (SF1) and are structurally very similar. In contrast, the HCV helicase belongs to a different super-family of helicases, SF2, and shows little sequence homology with the PcrA/Rep helicases. Yet, the HCV helicase is structurally similar to Rep/PcrA, suggesting preservation of structural scaffolds and relationships between helicase motifs across these two super-families. The comparison study presented here also reveals the existence of a new helicase motif in the SF1 family of helicases.

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