Oncogenic Cooperation Between SOCS Family Proteins and EGFR Identified Using a Drosophila Epithelial Transformation Model

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2012 Jul 18

PMID 22802531

Citations 46

Authors

Hector Herranz

Xin Hong

Nguyen Thanh Hung

P Mathijs Voorhoeve

Stephen M Cohen

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are emerging as cooperating factors that promote the activity of oncogenes in tumor formation and disease progression. This poses the challenge of identifying the miRNA targets responsible for these interactions. In this study, we identify the growth regulatory miRNA bantam and its target, Socs36E, as cooperating factors in EGFR-driven tumorigenesis and metastasis in a Drosophila model of epithelial transformation. bantam promotes growth by limiting expression of Socs36E, which functions as a negative growth regulator. Socs36E has only a modest effect on growth on its own, but behaves as a tumor suppressor in combination with EGFR activation. The human ortholog of SOCS36E, SOCS5, behaves as a candidate tumor suppressor in cellular transformation in cooperation with EGFR/RAS pathway activation.

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