Snail, Zeb and BHLH Factors in Tumour Progression: an Alliance Against the Epithelial Phenotype?

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2007 May 18

PMID 17508028

Citations 1618

Authors

Hector Peinado

David Olmeda

Amparo Cano

Affiliations

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Abstract

The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.

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