MicroRNAs in Drosophila Cancer Models

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2019 Sep 15

PMID 31520354

Citations 3

Authors

Moritz Sander

Hector Herranz

Affiliations

Soon will be listed here.

Abstract

MiRNAs are post-transcriptional regulators of gene expression which have been implicated in virtually all biological processes. MiRNAs are frequently dysregulated in human cancers. However, the functional consequences of aberrant miRNA levels are not well understood. Drosophila is emerging as an important in vivo tumor model, especially in the identification of novel cancer genes. Here, we review Drosophila studies which functionally dissect the roles of miRNAs in tumorigenesis. Ultimately, these advances help to understand the implications of miRNA dysregulation in human cancers.

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References

Cohen S . MicroRNAs in animal development. Editorial. Semin Cell Dev Biol. 2010; 21(7):727. DOI: 10.1016/j.semcdb.2010.07.004. View

Friedman R, Farh K, Burge C, Bartel D . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2008; 19(1):92-105. PMC: 2612969. DOI: 10.1101/gr.082701.108. View

Vidigal J, Ventura A . The biological functions of miRNAs: lessons from in vivo studies. Trends Cell Biol. 2014; 25(3):137-47. PMC: 4344861. DOI: 10.1016/j.tcb.2014.11.004. View

Alvarez-Saavedra E, Horvitz H . Many families of C. elegans microRNAs are not essential for development or viability. Curr Biol. 2010; 20(4):367-73. PMC: 2844791. DOI: 10.1016/j.cub.2009.12.051. View

Chen Y, Song S, Weng R, Verma P, Kugler J, Buescher M . Systematic study of Drosophila microRNA functions using a collection of targeted knockout mutations. Dev Cell. 2014; 31(6):784-800. DOI: 10.1016/j.devcel.2014.11.029. View

Park C, Jeker L, Carver-Moore K, Oh A, Liu H, Cameron R . A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012; 1(4):385-91. PMC: 3345170. DOI: 10.1016/j.celrep.2012.02.008. View

Herranz H, Cohen S . MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev. 2010; 24(13):1339-44. PMC: 2895193. DOI: 10.1101/gad.1937010. View

Posadas D, Carthew R . MicroRNAs and their roles in developmental canalization. Curr Opin Genet Dev. 2014; 27:1-6. PMC: 4125612. DOI: 10.1016/j.gde.2014.03.005. View

Mendell J, Olson E . MicroRNAs in stress signaling and human disease. Cell. 2012; 148(6):1172-87. PMC: 3308137. DOI: 10.1016/j.cell.2012.02.005. View

10.

Riquelme I, Letelier P, Riffo-Campos A, Brebi P, Roa J . Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer. Int J Mol Sci. 2016; 17(3):424. PMC: 4813275. DOI: 10.3390/ijms17030424. View

11.

Pinzon N, Li B, Martinez L, Sergeeva A, Presumey J, Apparailly F . microRNA target prediction programs predict many false positives. Genome Res. 2017; 27(2):234-245. PMC: 5287229. DOI: 10.1101/gr.205146.116. View

12.

Pal A, Kasinski A . Animal Models to Study MicroRNA Function. Adv Cancer Res. 2017; 135:53-118. PMC: 5860655. DOI: 10.1016/bs.acr.2017.06.006. View

13.

Chandra S, Vimal D, Sharma D, Rai V, Gupta S, Chowdhuri D . Role of miRNAs in development and disease: Lessons learnt from small organisms. Life Sci. 2017; 185:8-14. DOI: 10.1016/j.lfs.2017.07.017. View

14.

Calin G, Croce C . MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6(11):857-66. DOI: 10.1038/nrc1997. View

15.

Ventura A, Jacks T . MicroRNAs and cancer: short RNAs go a long way. Cell. 2009; 136(4):586-91. PMC: 3910108. DOI: 10.1016/j.cell.2009.02.005. View

16.

Iorio M, Croce C . MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med. 2012; 4(3):143-59. PMC: 3376845. DOI: 10.1002/emmm.201100209. View

17.

SALVADOR R, APRIL S, Lemberger L . Phentolamine activation of glycogenolysis in rat skeletal muscle. Biochem Pharmacol. 1968; 17(3):395-402. DOI: 10.1016/0006-2952(68)90249-9. View

18.

Jansson M, Lund A . MicroRNA and cancer. Mol Oncol. 2012; 6(6):590-610. PMC: 5528350. DOI: 10.1016/j.molonc.2012.09.006. View

19.

Hayes J, Peruzzi P, Lawler S . MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014; 20(8):460-9. DOI: 10.1016/j.molmed.2014.06.005. View

20.

Lu J, Getz G, Miska E, Alvarez-Saavedra E, Lamb J, Peck D . MicroRNA expression profiles classify human cancers. Nature. 2005; 435(7043):834-8. DOI: 10.1038/nature03702. View