The Role of Exercise and PGC1alpha in Inflammation and Chronic Disease

Overview

Journal Nature

Specialty Science

Date 2008 Jul 25

PMID 18650917

Citations 476

Authors

Christoph Handschin

Bruce M Spiegelman

Affiliations

Soon will be listed here.

Abstract

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

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