Monkeying Around with Cardiac Progenitors: Hope for the Future

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2010 Mar 26

PMID 20335651

Citations 5

Authors

Li Qian

Deepak Srivastava

Affiliations

Soon will be listed here.

Abstract

Multipotent cardiovascular progenitor cells derived from ES cells or induced pluripotent stem (iPS) cells are an intriguing source for stem cell-based therapies for congenital and acquired heart diseases. From a clinical perspective, the ideal cardiac progenitor cells are those that can proliferate, survive, and differentiate into multiple mature cardiac cell types when transplanted into normal or diseased heart. In this issue of JCI, Blin et al. report the isolation and characterization of a group of early mesodermal cardiovascular progenitor cells, induced by BMP2 and marked by the cell surface protein, stage-specific embryonic antigen 1 (SSEA-1). BMP2-induced SSEA-1+ cells were purified from ES and iPS cells and could be directed to differentiate into cardiomyocytes, endothelial cells, and smooth muscle cells by treatment with defined cytokines and signaling molecules. Most importantly, purified SSEA+ progenitor cells from Rhesus monkey ES cells engrafted into nonhuman primate hearts, in which they differentiated into cardiac cells without forming teratomas. These findings move the field another step closer to clinical use of ES or iPS cell-derived cardiovascular progenitors in cardiac repair.

Citing Articles

Recent Stem Cell Advances: Cord Blood and Induced Pluripotent Stem Cell for Cardiac Regeneration- a Review.

Medhekar S, Shende V, Chincholkar A Int J Stem Cells. 2016; 9(1):21-30.

PMID: 27426082 PMC: 4961100. DOI: 10.15283/ijsc.2016.9.1.21.

Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends.

Pawani H, Bhartiya D Indian J Med Res. 2013; 137(2):270-82.

PMID: 23563370 PMC: 3657850.

Prospective in vitro models of channelopathies and cardiomyopathies.

Kawaguchi N, Hayama E, Furutani Y, Nakanishi T Stem Cells Int. 2012; 2012:439219.

PMID: 22969812 PMC: 3437306. DOI: 10.1155/2012/439219.

Myocardial remodeling: cellular and extracellular events and targets.

Dixon J, Spinale F Annu Rev Physiol. 2011; 73:47-68.

PMID: 21314431 PMC: 3157311. DOI: 10.1146/annurev-physiol-012110-142230.

Human endothelial stem/progenitor cells, angiogenic factors and vascular repair.

Watt S, Athanassopoulos A, Harris A, Tsaknakis G J R Soc Interface. 2010; 7 Suppl 6:S731-51.

PMID: 20843839 PMC: 2988281. DOI: 10.1098/rsif.2010.0377.focus.

References

Yang L, Soonpaa M, Adler E, Roepke T, Kattman S, Kennedy M . Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008; 453(7194):524-8. DOI: 10.1038/nature06894. View

Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y . Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009; 460(7251):113-7. DOI: 10.1038/nature08191. View

Laugwitz K, Moretti A, Lam J, Gruber P, Chen Y, Woodard S . Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005; 433(7026):647-53. PMC: 5578466. DOI: 10.1038/nature03215. View

Wu S, Fujiwara Y, Cibulsky S, Clapham D, Lien C, Schultheiss T . Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006; 127(6):1137-50. DOI: 10.1016/j.cell.2006.10.028. View

Srivastava D, Ivey K . Potential of stem-cell-based therapies for heart disease. Nature. 2006; 441(7097):1097-9. DOI: 10.1038/nature04961. View

Moretti A, Caron L, Nakano A, Lam J, Bernshausen A, Chen Y . Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006; 127(6):1151-65. DOI: 10.1016/j.cell.2006.10.029. View

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K . Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861-72. DOI: 10.1016/j.cell.2007.11.019. View

Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B . A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest. 2010; 120(4):1125-39. PMC: 2846046. DOI: 10.1172/JCI40120. View

Yi B, Wernet O, Chien K . Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest. 2010; 120(1):20-8. PMC: 2798699. DOI: 10.1172/JCI40820. View

10.

Yu J, Vodyanik M, Smuga-Otto K, Antosiewicz-Bourget J, Frane J, Tian S . Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007; 318(5858):1917-20. DOI: 10.1126/science.1151526. View

11.

Park I, Zhao R, West J, Yabuuchi A, Huo H, Ince T . Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2007; 451(7175):141-6. DOI: 10.1038/nature06534. View

12.

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

13.

Kattman S, Huber T, Keller G . Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell. 2006; 11(5):723-32. DOI: 10.1016/j.devcel.2006.10.002. View

14.

van Laake L, Passier R, Monshouwer-Kloots J, Verkleij A, Lips D, Freund C . Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res. 2009; 1(1):9-24. DOI: 10.1016/j.scr.2007.06.001. View

15.

Passier R, van Laake L, Mummery C . Stem-cell-based therapy and lessons from the heart. Nature. 2008; 453(7193):322-9. DOI: 10.1038/nature07040. View

16.

Murry C, Keller G . Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell. 2008; 132(4):661-80. DOI: 10.1016/j.cell.2008.02.008. View

17.

Laflamme M, Chen K, Naumova A, Muskheli V, Fugate J, Dupras S . Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 2007; 25(9):1015-24. DOI: 10.1038/nbt1327. View