Pregenerative Medicine: Developmental Paradigms in the Biology of Cardiovascular Regeneration

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2010 Jan 7

PMID 20051633

Citations 33

Authors

B Alexander Yi

Oliver Wernet

Kenneth R Chien

Affiliations

Soon will be listed here.

Abstract

The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate diverse lineages during heart development. In this Review, we highlight this intersection of the "pregenerative" biology of heart progenitor cells and heart regeneration and discuss the longer term challenges and opportunities in moving toward a therapeutic goal of regenerative cardiovascular medicine.

Citing Articles

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Origin of cardiomyocytes in the adult heart.

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