Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I

Overview

Journal Case Rep Med

Publisher Wiley

Specialty General Medicine

Date 2009 Dec 24

PMID 20029672

Citations 10

Authors

Marike L D Broekman

Roelof Risselada

JooYeon Engelen-Lee

Wim G M Spliet

Bon H Verweij

Affiliations

Soon will be listed here.

Abstract

Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%-20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain. We present an NF1 patient who developed a high-grade astrocytoma in the posterior fossa and discuss possible pathophysiological mechanisms.

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