Wim G M Spliet
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Explore the profile of Wim G M Spliet including associated specialties, affiliations and a list of published articles.
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65
Citations
1859
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Recent Articles
1.
van Kessel E, Berendsen S, Baumfalk A, Venugopal H, Krijnen E, Spliet W, et al.
Neuro Oncol
. 2022 Feb;
24(10):1660-1670.
PMID: 35148403
Background: Cognitive impairment is a common and debilitating symptom in patients with diffuse glioma, and is the result of multiple factors. We hypothesized that molecular tumor characteristics influence neurocognitive functioning...
2.
Bongaarts A, Mijnsbergen C, Anink J, Jansen F, Spliet W, den Dunnen W, et al.
Cell Mol Neurobiol
. 2021 Oct;
42(8):2863-2892.
PMID: 34709498
Tuberous sclerosis complex (TSC) is a monogenic disorder caused by mutations in either the TSC1 or TSC2 gene, two key regulators of the mechanistic target of the rapamycin complex pathway....
3.
Korotkov A, Sim N, Luinenburg M, Anink J, van Scheppingen J, Zimmer T, et al.
Neuropathol Appl Neurobiol
. 2021 May;
47(6):796-811.
PMID: 33942341
Aims: Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway. Neurodevelopmental disorders, frequently present in TSC, are...
4.
Kobow K, Jabari S, Pieper T, Kudernatsch M, Polster T, Woermann F, et al.
Acta Neuropathol
. 2020 Sep;
140(6):881-891.
PMID: 32979071
Polymicrogyria (PMG) is a developmental cortical malformation characterized by an excess of small and frustrane gyration and abnormal cortical lamination. PMG frequently associates with seizures. The molecular pathomechanisms underlying PMG...
5.
Muhlebner A, van Scheppingen J, de Neef A, Bongaarts A, Zimmer T, Mills J, et al.
J Neuropathol Exp Neurol
. 2020 Sep;
79(10):1054-1064.
PMID: 32954437
Tuberous sclerosis complex (TSC) is a monogenetic disease that arises due to mutations in either the TSC1 or TSC2 gene and affects multiple organ systems. One of the hallmark manifestations...
6.
Berendsen S, Frijlink E, Kroonen J, Spliet W, Van Hecke W, Seute T, et al.
Neurooncol Adv
. 2020 Jul;
1(1):vdz025.
PMID: 32642660
Background: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance of these...
7.
Bongaarts A, de Jong J, Broekaart D, van Scheppingen J, Anink J, Mijnsbergen C, et al.
J Neuropathol Exp Neurol
. 2020 May;
79(7):777-790.
PMID: 32472129
Tuberous sclerosis complex (TSC), a rare genetic disorder caused by a mutation in the TSC1 or TSC2 gene, is characterized by the growth of hamartomas in several organs. This includes...
8.
Bongaarts A, van Scheppingen J, Korotkov A, Mijnsbergen C, Anink J, Jansen F, et al.
Brain
. 2019 Dec;
143(1):131-149.
PMID: 31834371
Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited neurocutaneous disorder caused by inactivating mutations in TSC1 or TSC2, key regulators of the mechanistic target of rapamycin complex 1 (mTORC1)...
9.
Veersema T, de Neef A, van Scheppingen J, Ferrier C, van Eijsden P, Gosselaar P, et al.
Int J Dev Neurosci
. 2019 Nov;
79:96-104.
PMID: 31770571
Recent studies suggested a possible association between malformations of cortical development and microvascular density. In this study we aimed to further elucidate the relation between microvascular density and cortical developmental...
10.
Berendsen S, van Bodegraven E, Seute T, Spliet W, Geurts M, Hendrikse J, et al.
PLoS One
. 2019 Oct;
14(10):e0222717.
PMID: 31603915
Introduction: The subventricular zone (SVZ) in the brain is associated with gliomagenesis and resistance to treatment in glioblastoma. In this study, we investigate the prognostic role and biological characteristics of...