Marike L D Broekman
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Explore the profile of Marike L D Broekman including associated specialties, affiliations and a list of published articles.
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147
Citations
2338
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Recent Articles
1.
Jessurun C, Siddi F, Nawabi N, Hulsbergen A, Lo Y, Jha R, et al.
J Neurooncol
. 2025 Feb;
PMID: 39918777
Purpose: Immune checkpoint inhibitors (ICI) are increasingly being administered to cancer patients, including those with brain metastases (BMs). However, in a subset of cancer patients, ICI have shown to paradoxically...
2.
Hinz F, Friedel D, Korshunov A, Ippen F, Bogumil H, Banan R, et al.
Acta Neuropathol
. 2025 Feb;
149(1):12.
PMID: 39899075
IDH-mutant astrocytomas are diffuse gliomas that are defined by characteristic mutations in IDH1 or IDH2 and do not have complete 1p/19q co-deletion. The established grading criteria include histological features of...
3.
van Opijnen M, Nabuurs R, de Vos F, Ramsoedh M, Verhoeff J, Geurts M, et al.
Brain Spine
. 2025 Jan;
4():103923.
PMID: 39823067
Introduction: The optimal treatment for recurrent glioblastoma patients remains not well-defined in international guidelines. On top of that, the availability of national guidelines is uncharted. Research Question: This study aimed...
4.
Vooijs M, Robertson F, Blitz S, Jungk C, Krieg S, Schucht P, et al.
Neurooncol Adv
. 2024 Dec;
6(1):vdae206.
PMID: 39687790
Background: Awake craniotomy (AC) is a technique that balances maximum resection and minimal postoperative deficits in patients with intracranial tumors. To aid in the comparability of functional outcomes after awake...
5.
Gerritsen J, Karschnia P, Young J, van den Bent M, Chang S, Smith T, et al.
Neuro Oncol
. 2024 Dec;
PMID: 39657588
Subgroup analyses are essential to generate new hypotheses or to estimate treatment effects in clinically meaningful subgroups of patients. They play an important role in taking the next step towards...
6.
Nieland L, Vrijmoet A, Jetten I, Rufino-Ramos D, de Reus A, Breyne K, et al.
Mol Ther
. 2024 Nov;
33(1):133-151.
PMID: 39563028
Glioblastoma (GB), the most aggressive tumor of the central nervous system (CNS), has poor patient outcomes with limited effective treatments available. MicroRNA-21 (miR-21(a)) is a known oncogene, abundantly expressed in...
7.
van Opijnen M, Sadigh Y, Dijkstra M, Young J, Krieg S, Ille S, et al.
J Neurooncol
. 2024 Nov;
171(3):485-493.
PMID: 39556284
Purpose: Previous evidence suggests that glioma re-resection can be effective in improving clinical outcomes. Furthermore, the use of mapping techniques during surgery has proven beneficial for newly diagnosed glioma patients....
8.
Karagianni M, Mihaylova S, Tzerefos C, Janssen I, Tsianaka E, Murphy M, et al.
J Clin Neurosci
. 2024 Oct;
129:110880.
PMID: 39447390
Background: Women in neurosurgery often have to delay pregnancy and child-rearing because the optimum time for having children overlap with an intense period of training and/or career advancement. The purpose...
9.
van Opijnen M, de Vos F, Cuppen E, Geurts M, Maas S, Broekman M
Med Oncol
. 2024 Sep;
41(11):250.
PMID: 39316248
For glioblastoma patients, the efficacy-targeted therapy is limited to date. Most of the molecular therapies previously studied are lacking efficacy in this population. More trials are needed to study the...
10.
van Solinge T, Oh J, Abels E, Koch P, Breakefield X, Weissleder R, et al.
Neoplasia
. 2024 Sep;
57:101051.
PMID: 39270598
The interaction between gliomas and the immune system is poorly understood and thus hindering development of effective immunotherapies for glioma patients. The immune response is highly variable during tumor development,...