The Aptamer Core of SAM-IV Riboswitches Mimics the Ligand-binding Site of SAM-I Riboswitches

Overview

Journal RNA

Specialty Molecular Biology

Date 2008 Mar 29

PMID 18369181

Citations 63

Authors

Zasha Weinberg

Elizabeth E Regulski

Ming C Hammond

Jeffrey E Barrick

Zizhen Yao

Walter L Ruzzo

Ronald R Breaker

Affiliations

Soon will be listed here.

Abstract

A novel family of riboswitches, called SAM-IV, is the fourth distinct set of mRNA elements to be reported that regulate gene expression via direct sensing of S-adenosylmethionine (SAM or AdoMet). SAM-IV riboswitches share conserved nucleotide positions with the previously described SAM-I riboswitches, despite rearranged structures and nucleotide positions with family-specific nucleotide identities. Sequence analysis and molecular recognition experiments suggest that SAM-I and SAM-IV riboswitches share similar ligand binding sites, but have different scaffolds. Our findings support the view that RNA has considerable structural versatility and reveal that riboswitches exploit this potential to expand the scope of RNA in genetic regulation.

Citing Articles

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