Potential Basis for Amphotericin B Resistance in Aspergillus Terreus

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2008 Feb 13

PMID 18268082

Citations 56

Authors

Gerhard Blum

Susanne Perkhofer

Hubertus Haas

Markus Schrettl

Reinhard Wurzner

Manfred P Dierich

Cornelia Lass-Florl

Affiliations

Soon will be listed here.

Abstract

This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.

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