Nonsterol Related Resistance in Ustilago Maydis to the Polyene Antifungals, Amphotericin B and Nystatin

Overview

Journal Phytochemistry

Publisher Elsevier

Specialties Biochemistry
Biology
Chemistry

Date 1996 Jun 1

PMID 8768319

Citations 5

Authors

T Joseph-Horne

N Manning

D Holoman

S Kelly

Affiliations

Soon will be listed here.

Abstract

Two amphotericin B resistant mutants of Ustilago maydis were isolated following direct selection from a wild-type population. Each mutant was demonstrated to be cross-resistant to nystatin yet remained sensitive to azoles. Sterol analysis indicated a sterol profile similar to the parent strain, precluding the involvement of an alteration in ergosterol biosynthesis as the cause of polyene resistance.

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