Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2008 Feb 7

PMID 18252209

Citations 209

Authors

Owen J Marshall

Anderly C Chueh

Lee H Wong

K H Andy Choo

Affiliations

Soon will be listed here.

Abstract

Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.

Citing Articles

CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids.

Cappelletti E, Piras F, Biundo M, Raimondi E, Nergadze S, Giulotto E Genome Biol. 2025; 26(1):23.

PMID: 39915813 PMC: 11804003. DOI: 10.1186/s13059-025-03490-0.

Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape.

Chabot B, Sun R, Amjad A, Hoyt S, Ouyang L, Courret C Genome Biol. 2024; 25(1):295.

PMID: 39558354 PMC: 11575011. DOI: 10.1186/s13059-024-03433-1.

Complete sequencing of ape genomes.

Yoo D, Rhie A, Hebbar P, Antonacci F, Logsdon G, Solar S bioRxiv. 2024; .

PMID: 39131277 PMC: 11312596. DOI: 10.1101/2024.07.31.605654.

Karyotype and LTR-RTs analysis provide insights into oak genomic evolution.

Cao R, Chen R, Liao K, Li H, Xu G, Jiang X BMC Genomics. 2024; 25(1):328.

PMID: 38566015 PMC: 10988972. DOI: 10.1186/s12864-024-10177-6.

The structure, function, and evolution of plant centromeres.

Naish M, Henderson I Genome Res. 2024; 34(2):161-178.

PMID: 38485193 PMC: 10984392. DOI: 10.1101/gr.278409.123.

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