Structural Genomics of Protein Phosphatases

Overview

Journal J Struct Funct Genomics

Specialty Genetics

Date 2007 Dec 7

PMID 18058037

Citations 73

Authors

Steven C Almo

Jeffrey B Bonanno

J Michael Sauder

Spencer Emtage

Teresa P DiLorenzo

Vladimir Malashkevich

Steven R Wasserman

S Swaminathan

Subramaniam Eswaramoorthy

Rakhi Agarwal

Desigan Kumaran

Mahendra Madegowda

Sugadev Ragumani

Yury Patskovsky

Johnjeff Alvarado

Udupi A Ramagopal

Joana Faber-Barata

Mark R Chance

Andrej Sali

Andras Fiser

Zhong-Yin Zhang

David S Lawrence

Stephen K Burley

Affiliations

Soon will be listed here.

Abstract

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

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