Spencer Emtage
Overview
Explore the profile of Spencer Emtage including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
13
Citations
931
Followers
0
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Recent Articles
1.
Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen L, Curtis C, et al.
J Biol Chem
. 2015 Apr;
290(22):13641-53.
PMID: 25825497
SMYD2 is a lysine methyltransferase that catalyzes the monomethylation of several protein substrates including p53. SMYD2 is overexpressed in a significant percentage of esophageal squamous primary carcinomas, and that overexpression...
2.
Antonysamy S, Bonday Z, Campbell R, Doyle B, Druzina Z, Gheyi T, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(44):17960-5.
PMID: 23071334
Protein arginine methyltransferases (PRMTs) play important roles in several cellular processes, including signaling, gene regulation, and transport of proteins and nucleic acids, to impact growth, differentiation, proliferation, and development. PRMT5...
3.
Kamat S, Holmes-Hampton G, Bagaria A, Kumaran D, Tichy S, Gheyi T, et al.
Protein Sci
. 2011 Oct;
20(12):2080-94.
PMID: 21998098
Adenine deaminase (ADE) from the amidohydrolase superfamily (AHS) of enzymes catalyzes the conversion of adenine to hypoxanthine and ammonia. Enzyme isolated from Escherichia coli was largely inactive toward the deamination...
4.
Foreman K, Brown M, Park F, Emtage S, Harriss J, Das C, et al.
PLoS One
. 2011 Jul;
6(7):e22290.
PMID: 21779408
The SET and MYND Domain (SMYD) proteins comprise a unique family of multi-domain SET histone methyltransferases that are implicated in human cancer progression. Here we report an analysis of the...
5.
Kikani C, Antonysamy S, Bonanno J, Romero R, Zhang F, Russell M, et al.
J Biol Chem
. 2010 Oct;
285(52):41034-43.
PMID: 20943661
Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) is an evolutionary conserved protein kinase that coordinates cellular metabolism with metabolic demand in yeast and mammals. The molecular mechanisms underlying PASK regulation, however,...
6.
Protasevich I, Yang Z, Wang C, Atwell S, Zhao X, Emtage S, et al.
Protein Sci
. 2010 Aug;
19(10):1917-31.
PMID: 20687133
Misfolding and degradation of CFTR is the cause of disease in patients with the most prevalent CFTR mutation, an in-frame deletion of phenylalanine (F508del), located in the first nucleotide-binding domain...
7.
Atwell S, Brouillette C, Conners K, Emtage S, Gheyi T, Guggino W, et al.
Protein Eng Des Sel
. 2010 Feb;
23(5):375-84.
PMID: 20150177
Upon removal of the regulatory insert (RI), the first nucleotide binding domain (NBD1) of human cystic fibrosis transmembrane conductance regulator (CFTR) can be heterologously expressed and purified in a form...
8.
Buchanan S, Hendle J, Lee P, Smith C, Bounaud P, Jessen K, et al.
Mol Cancer Ther
. 2009 Nov;
8(12):3181-90.
PMID: 19934279
The MET receptor tyrosine kinase has emerged as an important target for the development of novel cancer therapeutics. Activation of MET by mutation or gene amplification has been linked to...
9.
Sauder M, Rutter M, Bain K, Rooney I, Gheyi T, Atwell S, et al.
Methods Mol Biol
. 2008 Jun;
426:561-75.
PMID: 18542890
Phase II of the Protein Structure Initiative, funded by the NIH NIGMS (National Institute of General Medical Sciences), is a 5-year effort to determine thousands of protein structures. The New...
10.
Almo S, Bonanno J, Sauder J, Emtage S, DiLorenzo T, Malashkevich V, et al.
J Struct Funct Genomics
. 2007 Dec;
8(2-3):121-40.
PMID: 18058037
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of...