David S Lawrence
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Explore the profile of David S Lawrence including associated specialties, affiliations and a list of published articles.
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137
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2240
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Recent Articles
1.
Skrajna A, Bodrug T, Martinez-Chacin R, Fisher C, Welsh K, Simmons H, et al.
Nat Commun
. 2025 Mar;
16(1):2561.
PMID: 40089476
Non-degradative histone ubiquitylation plays a myriad of well-defined roles in the regulation of gene expression and choreographing DNA damage repair pathways. In contrast, the contributions of degradative histone ubiquitylation on...
2.
Ekusai-Sebatta D, Namugenyi R, Laker E, Mwaka E, King R, Lawrence D, et al.
Int Health
. 2025 Mar;
PMID: 40079128
Background: This article discusses the ethical issues surrounding the integration of long-acting injectable antiretroviral therapy (LA-ART) in the programmatic management of human immunodeficiency virus (HIV). As the medical landscape evolves,...
3.
Ainslie K, Bowers A, Chichewicz R, Collier L, Doorn J, Frei C, et al.
AAPS J
. 2025 Feb;
27(1):41.
PMID: 39904863
On October 29, 2024, a virtual meeting, brought together chairs and vice chairs from several research-oriented U.S. Schools of Pharmacy to discuss the current landscape of pharmaceutical sciences, advocacy strategies,...
4.
Acharya B, McGlade C, Yin H, Kawano T, Haar L, Mackman N, et al.
J Control Release
. 2024 Nov;
378:281-293.
PMID: 39615753
Occlusive blood clots remain a significant global health challenge and result in emergencies that are main causes of death and disability worldwide. Thrombolytic agents (including tissue plasminogen activator, tPA) are...
5.
Stott K, Mohabir J, Bowers K, Tenor J, Toffaletti D, Unsworth J, et al.
mBio
. 2024 Aug;
15(10):e0159224.
PMID: 39189739
Importance: HIV-associated cryptococcal meningitis is associated with a high burden of mortality. Research into the different strain types causing this disease has yielded inconsistent findings in terms of which strains...
6.
Gakuru J, Kagimu E, Dai B, Okurut S, Nsangi L, Bahr N, et al.
Clin Infect Dis
. 2024 Aug;
80(2):417-424.
PMID: 39180324
Background: In 2022, the World Health Organization (WHO) recommended a single 10 mg/kg dose of liposomal amphotericin B in combination with 14 days of flucytosine and fluconazole (AMBITION-cm regimen) for...
7.
Mambule I, Norcross C, Ombajo L, Sokhela S, Odongpiny E, Owarwo N, et al.
Lancet HIV
. 2024 May;
11(6):e419-e426.
PMID: 38697180
Two-drug regimens for the treatment of HIV are increasingly available. The oral regimen of dolutegravir plus lamivudine is recommended as a preferred option in multiple national guidelines but is not...
8.
Mbangiwa T, Sturny-Leclere A, Lechiile K, Kajanga C, Boyer-Chammard T, Hoving J, et al.
Lancet Microbe
. 2024 Feb;
5(3):e261-e271.
PMID: 38342110
Background: HIV-associated cryptococcal meningitis is the second leading cause of AIDS-related deaths, with a 10-week mortality rate of 25-30%. Fungal load assessed by colony-forming unit (CFU) counts is used as...
9.
Milburn J, Ntwayagae O, Suresh R, Ngoni K, Northcott C, Penney J, et al.
Clin Infect Dis
. 2024 Feb;
79(2):462-468.
PMID: 38330295
Background: Cryptococcal meningitis (CM) causes substantial mortality in African countries with a high prevalence of human immunodeficiency virus (HIV), despite advances in disease management and increasing antiretroviral therapy (ART) coverage....
10.
Lawrence D, Ssali A, Moshashane N, Nabaggala G, Maphane L, Harrison T, et al.
SSM Qual Res Health
. 2023 Dec;
4:100350.
PMID: 38106376
HIV-associated cryptococcal meningitis remains a key driver of AIDS-related mortality. Mortality is twice as high in those who present later to care and with severe symptoms such as confusion. We...