Protein Tyrosine Phosphatases: from Genes, to Function, to Disease

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2006 Oct 24

PMID 17057753

Citations 763

Authors

Nicholas K Tonks

Affiliations

Soon will be listed here.

Abstract

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.

Citing Articles

Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin.

Liu S, Pi J, Zhang Q Antioxidants (Basel). 2025; 14(2).

PMID: 40002419 PMC: 11852172. DOI: 10.3390/antiox14020235.

A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions.

Meeusen B, Ambjorn S, Veis J, Riley R, Vit G, Brauer B bioRxiv. 2025; .

PMID: 39990307 PMC: 11844454. DOI: 10.1101/2025.02.12.637884.

Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series.

Zhu G, Didry-Barca B, Seabra L, Rice G, Uggenti C, Touimy M Lancet Neurol. 2025; 24(3):218-229.

PMID: 39986310 PMC: 7617446. DOI: 10.1016/S1474-4422(24)00526-X.

What is known and unknown about the role of neuroendocrine genes and .

Stojilkovic S, Sokanovic S, Constantin S Front Endocrinol (Lausanne). 2025; 16:1531723.

PMID: 39926347 PMC: 11802530. DOI: 10.3389/fendo.2025.1531723.

Click Chemistry: an overview and recent updates in the medicinal attributes of click-derived heterocycles.

Bishnoi P, Saroha B, Kumar S, Kumar G, Bhardwaj A, Kumari M Mol Divers. 2025; .

PMID: 39918713 DOI: 10.1007/s11030-025-11110-z.