Plasmid-mediated KPC-2 in a Klebsiella Pneumoniae Isolate from China

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2006 Dec 6

PMID 17145797

Citations 104

Authors

Ze-qing Wei

Xiao-xing Du

Yun-Song Yu

Ping Shen

Ya-Gang Chen

Lan-Juan Li

Affiliations

Soon will be listed here.

Abstract

A carbapenem-resistant isolate of Klebsiella pneumoniae producing class A carbapenemase KPC-2 was identified in Zhejiang, China. The KPC-2 gene was located on an approximately 60-kb plasmid in a genetic environment partially different from that of blaKPC-2 in the isolates from the United States and Colombia.

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References

Ikonomidis A, Tokatlidou D, Kristo I, Sofianou D, Tsakris A, Mantzana P . Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a bla VIM-1 metallo-{beta}-lactamase gene. J Clin Microbiol. 2005; 43(10):5344-7. PMC: 1248513. DOI: 10.1128/JCM.43.10.5344-5347.2005. View

Wei Z, Chen Y, Yu Y, Lu W, Li L . Nosocomial spread of multi-resistant Klebsiella pneumoniae containing a plasmid encoding multiple beta-lactamases. J Med Microbiol. 2005; 54(Pt 9):885-888. DOI: 10.1099/jmm.0.46151-0. View

Lomaestro B, Tobin E, Shang W, Gootz T . The spread of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae to upstate New York. Clin Infect Dis. 2006; 43(3):e26-8. DOI: 10.1086/505598. View

Villegas M, Lolans K, Correa A, Suarez C, Lopez J, Vallejo M . First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrob Agents Chemother. 2006; 50(8):2880-2. PMC: 1538657. DOI: 10.1128/AAC.00186-06. View

Navon-Venezia S, Chmelnitsky I, Leavitt A, Schwaber M, Schwartz D, Carmeli Y . Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel. Antimicrob Agents Chemother. 2006; 50(9):3098-101. PMC: 1563531. DOI: 10.1128/AAC.00438-06. View

Yu Y, Du X, Zhou Z, Chen Y, Li L . First isolation of blaIMI-2 in an Enterobacter cloacae clinical isolate from China. Antimicrob Agents Chemother. 2006; 50(4):1610-1. PMC: 1426974. DOI: 10.1128/AAC.50.4.1610-1611.2006. View

Yigit H, Queenan A, Anderson G, Domenech-Sanchez A, Biddle J, Steward C . Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001; 45(4):1151-61. PMC: 90438. DOI: 10.1128/AAC.45.4.1151-1161.2001. View

Nordmann P, Poirel L . Emerging carbapenemases in Gram-negative aerobes. Clin Microbiol Infect. 2002; 8(6):321-31. DOI: 10.1046/j.1469-0691.2002.00401.x. View

Moland E, Hanson N, Herrera V, Black J, Lockhart T, Hossain A . Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates. J Antimicrob Chemother. 2003; 51(3):711-4. DOI: 10.1093/jac/dkg124. View

10.

Miriagou V, Tzouvelekis L, Rossiter S, Tzelepi E, Angulo F, Whichard J . Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2. Antimicrob Agents Chemother. 2003; 47(4):1297-300. PMC: 152505. DOI: 10.1128/AAC.47.4.1297-1300.2003. View

11.

Yigit H, Queenan A, Rasheed J, Biddle J, Domenech-Sanchez A, Alberti S . Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Antimicrob Agents Chemother. 2003; 47(12):3881-9. PMC: 296202. DOI: 10.1128/AAC.47.12.3881-3889.2003. View

12.

Poirel L, Heritier C, Tolun V, Nordmann P . Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2003; 48(1):15-22. PMC: 310167. DOI: 10.1128/AAC.48.1.15-22.2004. View

13.

Bradford P, Bratu S, Urban C, Visalli M, Mariano N, Landman D . Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City. Clin Infect Dis. 2004; 39(1):55-60. DOI: 10.1086/421495. View

14.

Hossain A, Ferraro M, Pino R, Dew 3rd R, Moland E, Lockhart T . Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp. Antimicrob Agents Chemother. 2004; 48(11):4438-40. PMC: 525415. DOI: 10.1128/AAC.48.11.4438-4440.2004. View

15.

Woodford N, Tierno Jr P, Young K, Tysall L, Palepou M, Ward E . Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center. Antimicrob Agents Chemother. 2004; 48(12):4793-9. PMC: 529220. DOI: 10.1128/AAC.48.12.4793-4799.2004. View

16.

Bratu S, Mooty M, Nichani S, Landman D, Gullans C, Pettinato B . Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection. Antimicrob Agents Chemother. 2005; 49(7):3018-20. PMC: 1168646. DOI: 10.1128/AAC.49.7.3018-3020.2005. View