» Articles » PMID: 17145797

Plasmid-mediated KPC-2 in a Klebsiella Pneumoniae Isolate from China

Overview
Specialty Pharmacology
Date 2006 Dec 6
PMID 17145797
Citations 104
Authors
Affiliations
Soon will be listed here.
Abstract

A carbapenem-resistant isolate of Klebsiella pneumoniae producing class A carbapenemase KPC-2 was identified in Zhejiang, China. The KPC-2 gene was located on an approximately 60-kb plasmid in a genetic environment partially different from that of blaKPC-2 in the isolates from the United States and Colombia.

Citing Articles

Carbapenem-resistant Klebsiella pneumoniae: Risk Factors for Isolation Among Hospitalized Patients.

Kobaidze K, Jacob J, Leong T, Flanders W Brown J Hosp Med. 2025; 2(1):57568.

PMID: 40046553 PMC: 11878813. DOI: 10.56305/001c.57568.


Disseminated organ and tissue infection secondary to carbapenem-resistant Klebsiella pneumoniae bloodstream infection for acute lymphoblastic leukemia treated with ceftazidime-avibactam: Two case reports.

He M, Jiang Y, Wu H, Xu X, Jiang H Medicine (Baltimore). 2025; 104(2):e41195.

PMID: 39792772 PMC: 11730841. DOI: 10.1097/MD.0000000000041195.


KleTy: integrated typing scheme for core genome and plasmids reveals repeated emergence of multi-drug resistant epidemic lineages in Klebsiella worldwide.

Li H, Liu X, Li S, Rong J, Xie S, Gao Y Genome Med. 2024; 16(1):130.

PMID: 39529172 PMC: 11556198. DOI: 10.1186/s13073-024-01399-0.


Characteristic of KPC-12, a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in the Carbapenem-Resistant ST11-KL47 Clone Background.

Han W, Zhou P, Chen C, Wu C, Shen L, Wan C Infect Drug Resist. 2024; 17:2541-2554.

PMID: 38933778 PMC: 11199322. DOI: 10.2147/IDR.S465699.


Apolipoprotein A-I levels in the survival of patients with colorectal cancer: a retrospective study.

Xie H, Wei L, Wang Q, Tang S, Gan J Front Endocrinol (Lausanne). 2024; 15:1318416.

PMID: 38919478 PMC: 11196595. DOI: 10.3389/fendo.2024.1318416.


References
1.
Ikonomidis A, Tokatlidou D, Kristo I, Sofianou D, Tsakris A, Mantzana P . Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a bla VIM-1 metallo-{beta}-lactamase gene. J Clin Microbiol. 2005; 43(10):5344-7. PMC: 1248513. DOI: 10.1128/JCM.43.10.5344-5347.2005. View

2.
Wei Z, Chen Y, Yu Y, Lu W, Li L . Nosocomial spread of multi-resistant Klebsiella pneumoniae containing a plasmid encoding multiple beta-lactamases. J Med Microbiol. 2005; 54(Pt 9):885-888. DOI: 10.1099/jmm.0.46151-0. View

3.
Lomaestro B, Tobin E, Shang W, Gootz T . The spread of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae to upstate New York. Clin Infect Dis. 2006; 43(3):e26-8. DOI: 10.1086/505598. View

4.
Villegas M, Lolans K, Correa A, Suarez C, Lopez J, Vallejo M . First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrob Agents Chemother. 2006; 50(8):2880-2. PMC: 1538657. DOI: 10.1128/AAC.00186-06. View

5.
Navon-Venezia S, Chmelnitsky I, Leavitt A, Schwaber M, Schwartz D, Carmeli Y . Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel. Antimicrob Agents Chemother. 2006; 50(9):3098-101. PMC: 1563531. DOI: 10.1128/AAC.00438-06. View