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Outbreaks in Distinct Regions Due to a Single Klebsiella Pneumoniae Clone Carrying a Bla VIM-1 Metallo-{beta}-lactamase Gene

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 2005 Oct 7
PMID 16208014
Citations 26
Authors
Alexandros Ikonomidis
Despina Tokatlidou
Ioulia Kristo
Danai Sofianou
Athanassios Tsakris
Paraskevi Mantzana
Spyros Pournaras
Antonios N Maniatis
Affiliations
Soon will be listed here.
Abstract

From December 2004 to March 2005, 27 Klebsiella pneumoniae clinical isolates that were positive by the imipenem-EDTA double-disk synergy test and that exhibited a single macro-restriction pattern were recovered in two distinct Greek hospitals. The isolates carried a transferable bla(VIM-1) metallo-beta-lactamase gene in a class 1 integron. Reverse transcriptase PCR showed that the gene was similarly expressed in low- and high-level carbapenem-resistant isolates, indicating the existence of additional resistance mechanisms. The clonal spread of VIM-1-producing K. pneumoniae strains in distinct regions where up to now bla(VIM-2) and bla(VIM-4) alleles were common is worrisome.

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