Plasmid-mediated Imipenem-hydrolyzing Enzyme KPC-2 Among Multiple Carbapenem-resistant Escherichia Coli Clones in Israel

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2006 Aug 31

PMID 16940107

Citations 65

Authors

Shiri Navon-Venezia

Inna Chmelnitsky

Azita Leavitt

Mitchell J Schwaber

David Schwartz

Yehuda Carmeli

Affiliations

Soon will be listed here.

Abstract

Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.

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