The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2004 May 5

PMID 15123745

Citations 73

Authors

Ninghai Wang

Abhay Satoskar

William Faubion

Duncan Howie

Susumu Okamoto

Stefan Feske

Charles Gullo

Kareem Clarke

Miriam Rodriguez Sosa

Arlene H Sharpe

Cox Terhorst

Affiliations

Soon will be listed here.

Abstract

Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus. Here we show that T cell receptor-induced interleukin (IL)-4 secretion by SLAM(-/-) CD4(+) cells is down-regulated, whereas interferon gamma production by CD4(+) T cells is only slightly up-regulated. Although SLAM controls production of IL-12, tumor necrosis factor, and nitric oxide in response to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG. Thus, SLAM acts as a coreceptor that regulates signals transduced by the major LPS receptor Toll-like receptor 4 on the surface of mouse macrophages. A defective macrophage function resulted in an inability of SLAM(-/-) C57Bl/6 mice to remove the parasite Leishmania major. We conclude that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.

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