Cox Terhorst
Overview
Explore the profile of Cox Terhorst including associated specialties, affiliations and a list of published articles.
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Articles
142
Citations
6180
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Recent Articles
1.
Cao D, Byrne B, de Jong Y, Terhorst C, Duan D, Herzog R, et al.
Hum Gene Ther
. 2024 Jun;
35(13-14):451-463.
PMID: 38887999
Adeno-associated virus (AAV) based viral vectors are widely used in human gene therapy and form the basis of approved treatments for several genetic diseases. Immune responses to vector and transgene...
2.
B cell focused transient immune suppression protocol for efficient AAV readministration to the liver
Rana J, Herzog R, Munoz-Melero M, Yamada K, Kumar S, Lam A, et al.
Mol Ther Methods Clin Dev
. 2024 Mar;
32(1):101216.
PMID: 38440160
Adeno-associated virus (AAV) vectors are used for correcting multiple genetic disorders. Although the goal is to achieve lifelong correction with a single vector administration, the ability to redose would enable...
3.
Kumar S, Biswas M, Cao D, Arisa S, Munoz-Melero M, Lam A, et al.
Mol Ther
. 2023 Dec;
32(2):325-339.
PMID: 38053332
Upon viral infection of the liver, CD8 T cell responses may be triggered despite the immune suppressive properties that manifest in this organ. We sought to identify pathways that activate...
4.
Biswas M, So K, Bertolini T, Krishnan P, Rana J, Munoz-Melero M, et al.
Front Immunol
. 2023 Nov;
14:1278184.
PMID: 37954612
Oral administration of antigen induces regulatory T cells (Treg) that can not only control local immune responses in the small intestine, but also traffic to the central immune system to...
5.
Rietdijk S, Keszei M, Castro W, Terhorst C, Abadia-Molina A
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902453
Ly108 (SLAMF6) is a homophilic cell surface molecule that binds SLAM-associated protein (SAP), an intracellular adapter protein that modulates humoral immune responses. Furthermore, Ly108 is crucial for the development of...
6.
Bertolini T, Herzog R, Kumar S, Sherman A, Rana J, Kaczmarek R, et al.
Cell Immunol
. 2023 Feb;
385:104675.
PMID: 36746071
Active tolerance to ingested dietary antigens forms the basis for oral immunotherapy to food allergens or autoimmune self-antigens. Alternatively, oral administration of anti-CD3 monoclonal antibody can be effective in modulating...
7.
Romero-Pinedo S, Barros D, Ruiz-Magana M, Maganto-Garcia E, Moreno de Lara L, Abadia-Molina F, et al.
Front Immunol
. 2022 Jul;
13:910112.
PMID: 35837407
Signaling lymphocytic activation molecule family 8 (SLAMF8) is involved in the negative modulation of NADPH oxidase activation. However, the impact of SLAMF8 downregulation on macrophage functionality and the microbicide mechanism...
8.
Butterfield J, Yamada K, Bertolini T, Syed F, Kumar S, Li X, et al.
Mol Ther
. 2022 Jul;
30(12):3552-3569.
PMID: 35821634
Hepatic adeno-associated viral (AAV) gene transfer has the potential to cure the X-linked bleeding disorder hemophilia A. However, declining therapeutic coagulation factor VIII (FVIII) expression has plagued clinical trials. To...
9.
Bertolini T, Biswas M, Terhorst C, Daniell H, Herzog R, Pineros A
Cell Immunol
. 2020 Nov;
359:104251.
PMID: 33248367
Oral antigen administration to induce regulatory T cells (Treg) takes advantage of regulatory mechanisms that the gastrointestinal tract utilizes to promote unresponsiveness against food antigens or commensal microorganisms. Recently, antigen-based...
10.
Fu S, Cunningham-Rundles C, Diamond B, Rotrosen D, Stohl W, Terhorst C
Clin Immunol
. 2020 Sep;
150(2):A1-A2.
PMID: 32942520
No abstract available.