Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/memory-like CD4+ Regulatory T Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2004 Feb 6

PMID 14757740

Citations 246

Authors

Jochen Huehn

Kerstin Siegmund

Joachim C U Lehmann

Christiane Siewert

Uta Haubold

Markus Feuerer

Gudrun F Debes

Joerg Lauber

Oliver Frey

Grzegorz K Przybylski

Uwe Niesner

Maurus de la Rosa

Christian A Schmidt

Rolf Brauer

Jan Buer

Alexander Scheffold

Alf Hamann

Affiliations

Soon will be listed here.

Abstract

Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.

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