A Cell-surface Molecule Involved in Organ-specific Homing of Lymphocytes

Overview

Journal Nature

Specialty Science

Date 1983 Jul 7

PMID 6866086

Citations 355

Authors

W M Gallatin

I L Weissman

E C Butcher

Affiliations

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Abstract

Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.

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