ILC Differentiation from Progenitors in the Bone Marrow

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2022 May 14

PMID 35567738

Authors

Arundhoti Das

Christelle Harly

Yi Ding

Avinash Bhandoola

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting extramedullary sites of ILC development. We also assess the contribution of development during different phases of life towards shaping the composition of the adult ILC pool. Finally, we briefly review the local cues that lead to heterogeneity of ILCs between tissues. We propose that tissue-resident ILC progenitors may economically allow tissues to elicit rapid expansion of specific ILC types that are needed based on the nature of antigenic assaults in tissues.

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