BlaCTX-M-2 is Located in an Unusual Class 1 Integron (In35) Which Includes Orf513

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2002 Jun 19

PMID 12069995

Citations 46

Authors

Sonia M Arduino

Paul H Roy

George A Jacoby

Betina E Orman

Silvia A Pineiro

Daniela Centron

Affiliations

Soon will be listed here.

Abstract

Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.

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