Zhu-Hong Li
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Explore the profile of Zhu-Hong Li including associated specialties, affiliations and a list of published articles.
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35
Citations
686
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Recent Articles
1.
Li Z, Asady B, Chang L, Triana M, Li C, Coppens I, et al.
bioRxiv
. 2024 Aug;
PMID: 39185237
Ca signaling in cells begins with the opening of Ca channels in either the plasma membrane (PM) or the endoplasmic reticulum (ER) and results in a dramatic increase in the...
2.
Sleda M, Li Z, Behera R, Baierna B, Li C, Jumpathong J, et al.
mBio
. 2022 Sep;
13(5):e0196622.
PMID: 36129297
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation,...
3.
Herneisen A, Li Z, Chan A, Moreno S, Lourido S
Elife
. 2022 Aug;
11.
PMID: 35976251
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specific cellular processes...
4.
Baek K, Phan T, Malwal S, Lee H, Li Z, Moreno S, et al.
Biomedicines
. 2022 Mar;
10(3).
PMID: 35327472
SQ109 is an anti-tubercular drug candidate that has completed Phase IIb/III clinical trials for tuberculosis and has also been shown to exhibit potent in vitro efficacy against protozoan parasites including...
5.
Gomaa F, Li Z, Beaudoin D, Alzan H, Girguis P, Docampo R, et al.
Environ Microbiol
. 2022 Jan;
24(7):3051-3062.
PMID: 35099107
Developing transfection protocols for marine protists is an emerging field that will allow the functional characterization of protist genes and their roles in organism responses to the environment. We developed...
6.
Li Z, King T, Ayong L, Asady B, Cai X, Rahman T, et al.
Nat Commun
. 2021 Oct;
12(1):5802.
PMID: 34608145
Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca-dependent events. Little is known about TPCs in...
7.
Vella S, Moore C, Li Z, Hortua Triana M, Potapenko E, Moreno S
Cell Calcium
. 2021 Feb;
94:102337.
PMID: 33524795
Toxoplasma gondii is an obligate intracellular parasite and replicates inside a parasitophorous vacuole (PV) within the host cell. The membrane of the PV (PVM) contains pores that permits for equilibration...
8.
McPhillie M, Zhou Y, Hickman M, Gordon J, Weber C, Li Q, et al.
Front Cell Infect Microbiol
. 2020 Jul;
10:203.
PMID: 32626661
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve...
9.
Cipriani M, Rostan S, Leon I, Li Z, Gancheff J, Kemmerling U, et al.
J Biol Inorg Chem
. 2020 Apr;
25(3):509-519.
PMID: 32232584
Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis and other bone illnesses. Some of them have also shown antiparasitic activity. In search of improving the pharmacological...
10.
Vella S, Calixto A, Asady B, Li Z, Moreno S
Methods Mol Biol
. 2019 Nov;
2071:187-207.
PMID: 31758454
Fluctuations of the cytosolic calcium ion (Ca) concentration regulate a variety of cellular functions in all eukaryotes. Cells express a sophisticated set of mechanisms to balance the cytosolic Ca levels...