Zhizhou Fang
Overview
Explore the profile of Zhizhou Fang including associated specialties, affiliations and a list of published articles.
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10
Citations
153
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Recent Articles
1.
Maurer C, Fang Z, Schindler C, Pohl G, Machrouhi-Porcher F, Lecomte M, et al.
RSC Med Chem
. 2025 Feb;
PMID: 39990161
Proteolysis-targeting chimeras (PROTACs©) have recently emerged as a promising new drug modality. Residing beyond the rule-of-five space, they pose challenges in terms of physicochemical properties. With this study, we contribute...
2.
Rollison H, Mitra P, Chanteux H, Fang Z, Liang X, Park S, et al.
Drug Metab Dispos
. 2024 May;
52(7):582-596.
PMID: 38697852
The International Consortium for Innovation and Quality in Pharmaceutical Development Transporter Working Group had a rare opportunity to analyze a crosspharma collation of in vitro data and assay methods for...
3.
Toure M, Johnson T, Li B, Schmidt R, Ma H, Neagu C, et al.
Bioorg Med Chem
. 2023 Aug;
92:117423.
PMID: 37531921
Hematopoietic progenitor kinase 1 (HPK1) is regarded as a highly validated target in pre-clinical immune oncology. HPK1 has been described as regulating multiple critical signaling pathway in both adaptive and...
4.
Qiu H, Ali Z, Bowlan J, Caldwell R, Gardberg A, Glaser N, et al.
ChemMedChem
. 2021 Sep;
16(24):3653-3662.
PMID: 34582626
Bruton's tyrosine kinase (BTK) is a member of the Tec kinase family that is expressed in cells of hematopoietic lineage. Evidence has shown that inhibition of BTK has clinical benefit...
5.
Qiu H, Ali Z, Bender A, Caldwell R, Chen Y, Fang Z, et al.
Bioorg Med Chem
. 2021 May;
40:116163.
PMID: 33932711
Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase member of the TEC family of tyrosine kinases. Pre-clinical and clinical data have shown that targeting BTK can be used...
6.
Ye D, Harder A, Fang Z, Weinheimer M, Laplanche L, Mezler M
Pharm Res
. 2020 Sep;
37(10):194.
PMID: 32918191
Purpose: We characterized three canine P-gp (cP-gp) deficient MDCKII cell lines. Their relevance for identifying efflux transporter substrates and predicting limitation of brain penetration were evaluated. In addition, we discuss...
7.
Bragelmann J, Dammert M, Dietlein F, Heuckmann J, Choidas A, Bohm S, et al.
Cell Rep
. 2017 Sep;
20(12):2833-2845.
PMID: 28930680
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found...
8.
Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, et al.
Angew Chem Int Ed Engl
. 2015 Jun;
54(35):10313-6.
PMID: 26110718
Targeting and stabilizing distinct kinase conformations is an instrumental strategy for dissecting conformation-dependent signaling of protein kinases. Herein the structure-based design, synthesis, and evaluation of pleckstrin homology (PH) domain-dependent covalent-allosteric...
9.
Fang Z, Simard J, Plenker D, Nguyen H, Phan T, Wolle P, et al.
ACS Chem Biol
. 2014 Jun;
10(1):279-88.
PMID: 24959717
In addition to the catalytically active kinase domain, most kinases feature regulatory domains that govern their activity. Modulating and interfering with these interdomain interactions presents a major opportunity for understanding...
10.
Schneider R, Gohla A, Simard J, Yadav D, Fang Z, van Otterlo W, et al.
J Am Chem Soc
. 2013 May;
135(22):8400-8.
PMID: 23672540
In the attempt to discover novel chemical scaffolds that can modulate the activity of disease-associated enzymes, such as kinases, biochemical assays are usually deployed in high-throughput screenings. First-line assays, such...