Zhengxian Gu
Overview
Explore the profile of Zhengxian Gu including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
156
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Srinivas Kandadai A, Bai B, Rahim M, Lin F, Gu Z, Qi X, et al.
Bioorg Med Chem
. 2023 Apr;
85:117276.
PMID: 37037115
Many non-nucleoside human cytomegalovirus (HCMV) inhibitors have been reported in patent and scientific literature, however, none have reached commercialization despite the urgent need for new HCMV treatments. Herein we report...
2.
Hu Y, Sun F, Yuan Q, Du J, Hu L, Gu Z, et al.
Bioorg Med Chem Lett
. 2022 Sep;
75:128977.
PMID: 36089112
Chronic hepatitis B (CHB) remains a significant health challenge worldwide. The current treatments for CHB achieve less than 10% cure rates, majority of the patients are on therapy for life....
3.
Bai B, Belovodskiy A, Hena M, Srinivas Kandadai A, Joyce M, Saffran H, et al.
J Med Chem
. 2021 Jul;
65(4):2905-2925.
PMID: 34242027
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses....
4.
Li P, Wu S, Xiao T, Li Y, Su Z, Wei W, et al.
Bioorg Med Chem
. 2020 Jun;
28(12):115551.
PMID: 32503695
We describe here the design, synthesis, and evaluation of a macrocyclic peptidomimetic as a potent agent targeting enterovirus A71 (EV71). The compound has a 15-membered macrocyclic ring in a defined...
5.
Tao X, Wang N, Wang J, Fu Z, Gu Z, Zhang Y, et al.
Antimicrob Agents Chemother
. 2019 Sep;
63(12).
PMID: 31527036
Amphihevir, a benzofuran derivative, is the first reported NS4B inhibitor that has advanced to clinical trials (currently in Phase Ib). Here, we report the results of a preclinical study of...
6.
Shi W, Jiang Z, He H, Xiao F, Lin F, Sun Y, et al.
ACS Med Chem Lett
. 2018 Apr;
9(4):397.
PMID: 29671838
[This corrects the article DOI: 10.1021/acsmedchemlett.7b00418.].
7.
Mou J, Wu S, Luo Z, Guo F, He H, Wang J, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(10):1874-1878.
PMID: 29650287
A series of caspase inhibitors containing γ-amino acid moiety have been synthesized. A systemic study on their structure-activity relationship of anti-apoptotic cellular activity is presented. These efforts led to the...
8.
Shi W, Jiang Z, He H, Xiao F, Lin F, Sun Y, et al.
ACS Med Chem Lett
. 2018 Feb;
9(2):94-97.
PMID: 29456794
A new series of 3,3'-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead...
9.
Li X, Zhou K, He H, Zhou Q, Sun Y, Hou L, et al.
ACS Med Chem Lett
. 2017 Sep;
8(9):969-974.
PMID: 28947946
The discovery of novel tetrahydropyrrolo[1,2-]pyrimidines derivatives from as hepatitis B virus (HBV) inhibitors is herein reported. The structure-activity relationship optimization led to one highly efficacious compound (IC = 10 nM)...
10.
Li P, Yu J, Hao F, He H, Shi X, Hu J, et al.
ACS Med Chem Lett
. 2017 Aug;
8(8):841-846.
PMID: 28835799
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences....