Zachary J Streblow
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Explore the profile of Zachary J Streblow including associated specialties, affiliations and a list of published articles.
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9
Citations
12
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Recent Articles
1.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Sci Rep
. 2025 Mar;
15(1):7264.
PMID: 40025188
Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a...
2.
Otero C, Petkova S, Ebermann M, Taher H, John N, Hoffmann K, et al.
Nat Commun
. 2025 Jan;
16(1):1200.
PMID: 39885150
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role in infection and pathogenesis is unknown. To examine their in vivo function...
3.
Medica S, Denton M, Diggins N, Kramer-Hansen O, Crawford L, Mayo A, et al.
J Virol
. 2024 Dec;
99(1):e0180124.
PMID: 39655954
The human cytomegalovirus (HCMV) encoded chemokine receptor US28 plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Despite...
4.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Res Sq
. 2024 Nov;
PMID: 39606462
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio...
5.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2409166121.
PMID: 39388272
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection....
6.
Weber W, Andoh T, Kreklywich C, Streblow Z, Denton M, Streblow M, et al.
Vaccines (Basel)
. 2024 Sep;
12(9).
PMID: 39340002
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use. Mayaro virus (MAYV) is a related emerging alphavirus...
7.
Weber W, Streblow Z, Kreklywich C, Denton M, Sulgey G, Streblow M, et al.
Vaccines (Basel)
. 2024 Aug;
12(8).
PMID: 39204019
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major...
8.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
bioRxiv
. 2024 Apr;
PMID: 38562906
Significance Statement: Chikungunya virus is one of the most prominent and widespread alphaviruses and has caused explosive outbreaks of arthritic disease. Currently, there are no FDA-approved drugs to treat disease...
9.
Otero C, Petkova S, Ebermann M, Taher H, John N, Hoffmann K, et al.
bioRxiv
. 2024 Mar;
PMID: 38464092
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation , but their role in infection and pathogenesis is unknown. To examine the function of vFcγRs in...
10.
Jones I, Orloff S, Burg J, Haese N, Andoh T, Chambers A, et al.
Am J Transplant
. 2021 Jan;
21(1):44-59.
PMID: 33405337
Ischemia-reperfusion injury (IRI) is an important risk factor for accelerated cardiac allograft rejection and graft dysfunction . Utilizing a rat heart isogeneic transplant model, we identified inflammatory pathways involved in...