Yusuke Hirata
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Explore the profile of Yusuke Hirata including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Otani K, Komatsu R, Noguchi T, Suzuki W, Hirata Y, Matsuzawa A
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076859
I3MT-3 (HMPSNE) has been identified as a selective inhibitor of the supersulfide-producing enzyme 3-MST. In this study, we found that I3MT-3 inhibits inflammatory responses, including the secretion of the pro-inflammatory...
2.
Kagi T, Tan M, Suzuki W, Otani K, Suzuki S, Hirata Y, et al.
J Toxicol Sci
. 2025 Jan;
50(1):11-21.
PMID: 39779228
A representative surfactant, benzalkonium chloride (BAC) is used as a disinfectant, but sometimes causes serious side effects, including lung disorders such as interstitial pneumonia. However, its pathogenic mechanisms remain unexplained....
3.
Roy B, Kojima R, Shah O, Shieh M, Das E, Ezzatpour S, et al.
Redox Biol
. 2024 Dec;
79():103475.
PMID: 39721494
Thiyl radicals are important reactive sulfur species and can cause cis to trans isomerization on unsaturated fatty acids. However, biocompatible strategies for the controlled generation of thiyl radicals are still...
4.
Hirata Y, Yamada Y, Taguchi S, Kojima R, Masumoto H, Kimura S, et al.
Cell Death Dis
. 2024 Dec;
15(12):884.
PMID: 39643606
Conjugated fatty acids (CFAs) have been known for their anti-tumor activity. However, the mechanism of action remains unclear. Here, we identify CFAs as inducers of glutathione peroxidase 4 (GPX4) degradation...
5.
Ogata H, Imaizumi A, Fujioka Y, Shimizu H, Hirata Y, Matsuzawa A, et al.
Anticancer Res
. 2024 Dec;
44(12):5215-5218.
PMID: 39626935
Background/aim: Pancreatic cancer is a major cause of mortality in the world. It is one of most aggressive diseases, with a 5-year survival rate of <10%. Cancer associated fibroblasts (CAFs)...
6.
Hirata Y, Nakata Y, Komatsu H, Kudoh Y, Takahashi M, Taguchi S, et al.
Free Radic Biol Med
. 2024 May;
221:31-39.
PMID: 38729452
Reactive oxygen species (ROS) are highly reactive and their accumulation causes oxidative damage to cells. Cells maintain survival upon mild oxidative stress with anti-oxidative systems, such as the kelch-like ECH-associated...
7.
Yokosawa T, Miyagawa S, Suzuki W, Nada Y, Hirata Y, Noguchi T, et al.
Cells
. 2024 Apr;
13(8.
PMID: 38667302
Toll-like receptors (TLRs) induce innate immune responses through activation of intracellular signaling pathways, such as MAP kinase and NF-κB signaling pathways, and play an important role in host defense against...
8.
Kagi T, Inoue A, Noguchi T, Suzuki W, Takano S, Otani K, et al.
J Immunol
. 2024 Apr;
212(11):1807-1818.
PMID: 38639584
Drug-induced acute renal failure (ARF) is a public health concern that hinders optimal drug therapy. However, pathological mechanisms of drug-induced ARF remain to be elucidated. Here, we show that a...
9.
Hamano S, Noguchi T, Asai Y, Ito R, Komatsu R, Sato T, et al.
Cell Death Discov
. 2024 Feb;
10(1):74.
PMID: 38346947
Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) triggers a noncanonical form of programmed cell death (PCD) called parthanatos, yet the mechanisms of its induction are not fully understood. We have recently...
10.
Hirata Y, Mishima E
Physiology (Bethesda)
. 2024 Jan;
39(2):73-87.
PMID: 38193763
Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the...