Membrane Dynamics and Cation Handling in Ferroptosis

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2024 Jan 9

PMID 38193763

Authors

Yusuke Hirata

Eikan Mishima

Affiliations

Soon will be listed here.

Abstract

Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion homeostasis via the cation channels, ultimately resulting in plasma membrane rupture. This review illuminates cellular membrane dynamics and cation handling in ferroptosis regulation.

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