Yusuke Hirasawa
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Explore the profile of Yusuke Hirasawa including associated specialties, affiliations and a list of published articles.
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Articles
121
Citations
738
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Recent Articles
1.
Hirasawa Y, Kasagi C, Koyama E, Myojin H, Tougan T, Horii T, et al.
J Nat Med
. 2024 Nov;
79(1):134-142.
PMID: 39540962
Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of...
2.
Nakajima Y, Nishino H, Takahashi K, Nugroho A, Hirasawa Y, Kaneda T, et al.
J Nat Med
. 2024 Sep;
79(1):36-44.
PMID: 39283364
Previously, we reported that azamollugin, an aza-derivative of mollugin, exhibited potent inhibitory activity on NO production in LPS-stimulated RAW 264.7 cells. Further investigations in this study revealed that azamollugin not...
3.
Hirasawa Y, Kakizoe Y, Tougan T, Uchiyama N, Horii T, Morita H
J Nat Med
. 2024 Apr;
78(3):768-773.
PMID: 38564155
A novel trimeric monoterpenoid indole alkaloid, vincarostine A (1) consisting of an aspidosperma-iboga-aspidosperma type skeleton, was isolated from the whole plant of Catharanthus roseus. The structure including absolute stereochemistry was...
4.
Nakajima Y, Tsuboi N, Katori K, Waili M, Nugroho A, Takahashi K, et al.
J Nat Med
. 2024 Apr;
78(3):568-575.
PMID: 38564154
Oxomollugin is a degraded product of mollugin and was found to be an active compound that inhibits LPS-induced NF-κB activation. In this study, we investigated the inhibitory activity of oxomollugin,...
5.
Hirasawa Y, Kase A, Okamoto A, Suzuki K, Hiroki M, Kaneda T, et al.
J Nat Med
. 2024 Feb;
78(2):382-392.
PMID: 38347371
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled...
6.
Nugroho A, Komuro T, Kawaguchi T, Shindo Y, Wong C, Hirasawa Y, et al.
J Nat Med
. 2023 Sep;
78(1):68-77.
PMID: 37690111
Ceramicines are a series of limonoids which were isolated from the barks of Malaysian Chisocheton ceramicus (Meliaceae), and were known to show various biological activity. Six new limonoids, ceramicines U-Z...
7.
Hiroki M, Abulikemu A, Totsuka C, Hirasawa Y, Kaneda T, Morita H
J Nat Med
. 2023 Sep;
78(1):216-225.
PMID: 37668823
A dimeric indole alkaloid, isovincathicine consisting of an aspidosperma type and modified iboga with C-7-C-20 connection type skeletons was first isolated from Catharanthus roseus, and the structure including stereochemistry was...
8.
Huang Y, Yokoe H, Kaiho-Soma A, Takahashi K, Hirasawa Y, Morita H, et al.
Bioconjug Chem
. 2023 Aug;
34(9):1716-1717.
PMID: 37642326
No abstract available.
9.
Hirasawa Y, Hattori R, Ohtani M, Morita H
J Nat Med
. 2023 May;
77(3):610-613.
PMID: 37171655
A new CN-type Lycopodium alkaloid consisting of two decahydroquinolines and a piperidine, cryptadine C (1) was isolated from Lycopodium cryptomerinum. The structure and relative configuration of 1, which is related...
10.
Nugroho A, Wong C, Hirasawa Y, Kaneda T, Tougan T, Horii T, et al.
J Nat Med
. 2023 May;
77(3):596-603.
PMID: 37162697
Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T...