Yukihiro Nishio
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Explore the profile of Yukihiro Nishio including associated specialties, affiliations and a list of published articles.
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31
Citations
417
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Recent Articles
11.
Nishio Y, Kimura H, Sawada N, Sugaru E, Horiguchi M, Ono M, et al.
Bioorg Med Chem
. 2011 Aug;
19(18):5490-9.
PMID: 21865048
We report on the identification of 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727) (7a) as a potent and orally active DPP-4 inhibitor without mechanism-based inactivation of CYP3A. Compound 7a showed good DPP-4 inhibitory activity (IC(50)=1.1...
12.
Egawa-Takata T, Ueda Y, Kuragaki C, Miyake T, Miyatake T, Fujita M, et al.
Cancer Chemother Pharmacol
. 2011 May;
68(6):1603-10.
PMID: 21584840
Background: TAP chemotherapy (paclitaxel, doxorubicin, and cisplatin) is effective for advanced and recurrent endometrial carcinoma, but has occasional severe toxicity. TEC chemotherapy (paclitaxel, epirubicin, and carboplatin) has been suggested to...
13.
Nishio Y, Kimura H, Tosaki S, Sugaru E, Sakai M, Horiguchi M, et al.
Bioorg Med Chem Lett
. 2010 Nov;
20(24):7246-9.
PMID: 21074430
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was...
14.
Mabuchi S, Kawase C, Altomare D, Morishige K, Hayashi M, Sawada K, et al.
Mol Cancer Ther
. 2010 Jul;
9(8):2411-22.
PMID: 20663925
This study examines the role of vascular endothelial growth factor (VEGF) as a therapeutic target in clear cell carcinoma (CCC) of the ovary, which has been regarded as a chemoresistant...
15.
Yasuoka H, Tsujimoto M, Fujita S, Yamasaki T, Kashihara H, Nishio Y, et al.
Int J Gynecol Pathol
. 2009 Jun;
28(4):362-6.
PMID: 19483627
A rare case of a clear cell adenocarcinoma and an adenosarcoma coexisting with a heterologous rhabdomyosarcoma in an endometriotic cyst of the ovary is reported. The tumor was composed of...
16.
Muraji M, Mabuchi S, Hisamoto K, Muranishi M, Kanagawa T, Nishio Y, et al.
Acta Obstet Gynecol Scand
. 2009 Mar;
88(6):720-3.
PMID: 19330563
Three cases of cesarean scar pregnancy successfully treated with methotrexate are described. The diagnosis was confirmed by transvaginal sonographic examinations showing a well-formed gestational sac in the myometrium of the...
17.
Sawada K, Morishige K, Nishio Y, Hayakawa J, Mabuchi S, Isobe A, et al.
J Bone Miner Metab
. 2009 Jan;
27(2):175-81.
PMID: 19152069
A forearm fracture (Colles' fracture) is often the first sign of osteoporosis and may suggest underlying skeletal fragility. Therefore, establishment of a more accurate and reliable method for the measurement...
18.
Yasuoka H, Tsujimoto M, Fujita S, Kunishige I, Nishio Y, Kodama R, et al.
Int J Gynecol Pathol
. 2008 Dec;
28(1):55-8.
PMID: 19047907
A rare case of mixed carcinoma of the ovary is reported, composed of a large cell neuroendocrine carcinoma and a mucinous borderline endocervical tumor. The large cell neuroendocrine carcinoma was...
19.
Sawada K, Morishige K, Ohmichi M, Nishio Y, Yamamoto T, Hayakawa J, et al.
Maturitas
. 2006 Oct;
56(4):343-9.
PMID: 17010541
Objective: A forearm fracture (Colles' fracture) is often the first sign of osteoporosis and should alert the patient and physician to the possibility of underlying skeletal fragility. Therefore, the establishment...
20.
Yada-Hashimoto N, Nishio Y, Ohmichi M, Hayakawa J, Mabuchi S, Hisamoto K, et al.
Menopause
. 2006 Sep;
13(6):935-41.
PMID: 17006379
Objective: To investigate the effects of estradiol (E2) and raloxifene on the migration of human monocytic THP-1 cells to endothelium. Design: A prospective comparative study. THP-1 cells, a human acute...