Yuhsin Kuo
Overview
Explore the profile of Yuhsin Kuo including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
224
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Recent Articles
1.
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
Loughran H, Schirripa K, Roecker A, Breslin M, Tong L, Fillgrove K, et al.
ACS Med Chem Lett
. 2024 Jan;
15(1):123-131.
PMID: 38229758
Inhibition of glucosylceramide synthase (GCS) has been proposed as a therapeutic strategy for the treatment of Parkinson's Disease (PD), particularly in patients where glycosphingolipid accumulation and lysosomal impairment are thought...
2.
Menzel K, Kuo Y, Chen D, Hartmann G, Wang Y, Cho C, et al.
Clin Transl Sci
. 2023 Apr;
16(6):1039-1048.
PMID: 37085998
Letermovir is approved for use in cytomegalovirus-seropositive hematopoietic stem cell transplant recipients and is investigated in other transplant settings. Nonlinear pharmacokinetics (PKs) were observed in clinical studies after intravenous and...
3.
Roecker A, Schirripa K, Loughran H, Tong L, Liang T, Fillgrove K, et al.
ACS Med Chem Lett
. 2023 Feb;
14(2):146-155.
PMID: 36793422
Parkinson's disease is the second most prevalent progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Loss-of-function mutations in GBA, the gene that encodes for...
4.
Yee K, Cabalu T, Kuo Y, Fillgrove K, Liu Y, Triantafyllou I, et al.
J Clin Pharmacol
. 2020 Sep;
61(3):394-405.
PMID: 32989795
Doravirine, a novel nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus 1 (HIV-1), is predominantly cleared by cytochrome P450 (CYP) 3A4 and metabolized to an oxidative metabolite...
5.
Ma B, Eisenhandler R, Kuo Y, Rearden P, Li Y, Manley P, et al.
Eur J Drug Metab Pharmacokinet
. 2016 Apr;
42(2):319-326.
PMID: 27101423
Background And Objectives: Prediction of metabolic clearance has been a challenge for compounds exhibiting minimal turnover in typical in vitro stability experiments. The aim of the current study is to...
6.
Pero J, Rossi M, Kelly 3rd M, Lehman H, Layton M, Garbaccio R, et al.
ACS Med Chem Lett
. 2016 Mar;
7(3):312-7.
PMID: 26985321
Investigation of a novel amino-aza-benzimidazolone structural class of positive allosteric modulators (PAMs) of metabotropic glutamate receptor 2 (mGluR2) identified [2.2.2]-bicyclic amine 12 as an intriguing lead structure due to its...
7.
Layton M, Reif A, Hartingh T, Rodzinak K, Dudkin V, Wang C, et al.
Bioorg Med Chem Lett
. 2016 Jan;
26(4):1260-4.
PMID: 26810316
Optimization of a benzimidazolone template for potency and physical properties revealed 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as a key template on which to develop a new series of mGlu2 positive allosteric modulators (PAMs). Systematic...
8.
Yang Z, Schlegel K, Shu Y, Reger T, Cube R, Mattern C, et al.
ACS Med Chem Lett
. 2014 Jun;
1(9):504-9.
PMID: 24900239
A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the...
9.
Garbaccio R, Brnardic E, Fraley M, Hartman G, Hutson P, OBrien J, et al.
ACS Med Chem Lett
. 2014 Jun;
1(8):406-10.
PMID: 24900224
Novel oxazolobenzimidazoles are described as potent and selective positive allosteric modulators of the metabotropic glutamate receptor 2. The discovery of this class and optimization of its physical and pharmacokinetic properties...
10.
Barrow J, Rittle K, Reger T, Yang Z, Bondiskey P, McGaughey G, et al.
ACS Med Chem Lett
. 2014 Jun;
1(2):75-9.
PMID: 24900180
A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of...