Yuan C Lee
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Explore the profile of Yuan C Lee including associated specialties, affiliations and a list of published articles.
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51
Citations
1042
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Recent Articles
1.
Schnaar R, Lee Y
Glycobiology
. 2017 Sep;
27(6):513-517.
PMID: 28922867
Sialic acids have a special place in vertebrate glycobiology, where they constitute the dominant terminal saccharides on many cell surface glycans. From early studies that identified sialoglycans as receptors for...
2.
Utratna M, Annuk H, Gerlach J, Lee Y, Kane M, Kilcoyne M, et al.
Sci Rep
. 2017 Jul;
7(1):6477.
PMID: 28743896
There is an urgent need for discovery of novel antimicrobials and carbohydrate-based anti-adhesive strategies are desirable as they may not promote resistance. Discovery of novel anti-adhesive molecules from natural product...
3.
Tomiya N, Jardim J, Hou J, Pastrana-Mena R, Dinglasan R, Lee Y
Bioorg Med Chem
. 2013 Jul;
21(17):5275-81.
PMID: 23859775
We have synthesized poly-γ-glutamic acid (PGA) modified with a synthetic trivalent glyco-ligand (TriGalNAc) for the hepatocyte asialoglycoprotein receptor (ASGP-R). We investigated in vivo distribution of unmodified PGA and TriGalNAc-modified PGA...
4.
Webb K, Yu J, Robinson C, Noboru T, Lee Y, DiRuggiero J
Extremophiles
. 2013 Mar;
17(3):485-97.
PMID: 23532412
Ionizing radiation (IR) is of particular interest in biology because its exposure results in severe oxidative stress to the cell's macromolecules. Our recent work with extremophiles supports the idea that...
5.
Lee R, Wang M, Lin W, Lee Y
Bioorg Med Chem
. 2011 Apr;
19(8):2494-500.
PMID: 21459583
New multi-valent, carbohydrate ligands that contain terminal N-acetylgalactosamine (GalNAc) or lactose (Lac) were prepared using a nitrilotriacetic acid (NTA) derivative of L-lysine as scaffold. Tri-valent structures were prepared by attaching...
6.
Hwu J, Hsu C, Hsu M, Liang Y, Huang R, Lee Y
Bioorg Med Chem Lett
. 2010 Dec;
21(1):380-2.
PMID: 21123067
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found...
7.
Lee R, Hsu T, Huang S, Hsieh S, Wong C, Lee Y
Glycobiology
. 2010 Nov;
21(4):512-20.
PMID: 21112966
C-type lectins (CTLs) are proteins that contain one or more carbohydrate-recognition domains (CRDs) that require calcium for sugar binding and share high degree of sequence homology and tertiary structure. CTLs...
8.
Zhou Y, Kawasaki H, Hsu S, Lee R, Yao X, Plunkett B, et al.
Nat Med
. 2010 Sep;
16(10):1128-33.
PMID: 20835248
We propose that a C-type lectin receptor, SIGNR-1 (also called Cd209b), helps to condition dendritic cells (DCs) in the gastrointestinal lamina propria (LPDCs) for the induction of oral tolerance in...
9.
Hsu S, Chen C, Tsai S, Kawasaki H, Hung C, Chu Y, et al.
J Biol Chem
. 2010 Jan;
285(11):7903-10.
PMID: 20080962
Fucosylated glycans on pathogens are known to shape the immune response through their interaction with pattern recognition receptors, such as C-type lectin receptors (CLRs), on dendritic cells (DCs). Similar fucosylated...
10.
Liu J, Chen W, Li C, Mong K, Tsai P, Tsai T, et al.
Analyst
. 2009 Sep;
134(10):2087-94.
PMID: 19768218
PA-IL is a galactophilic lectin that is found on the outer membrane of Pseudomonas aeruginosa. Pigeon ovalbumin (POA), a phosphoprotein, contains high levels of terminal Gal alpha(1-->4)Gal units. Thus, magnetic...