Yu-Lin Leu
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Explore the profile of Yu-Lin Leu including associated specialties, affiliations and a list of published articles.
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13
Citations
108
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Recent Articles
1.
Ho K, Liu Y, Huang B, Hong S, Yang S, Liao T, et al.
Int J Biol Macromol
. 2025 Jan;
300:140138.
PMID: 39842595
Glycosidic switch liposome (GSL) technology efficiently encapsulates and stabilizes potent anticancer drugs in liposomes using a reversible glucuronide ester. Enzymatic hydrolysis of the glucuronide switch in target cell lysosomes produces...
2.
Tseng Y, Lin H, Lin S, Chen B, Vo T, Yang S, et al.
J Control Release
. 2024 Feb;
369:179-198.
PMID: 38368947
Engineering human enzymes for therapeutic applications is attractive but introducing new amino acids may adversely affect enzyme stability and immunogenicity. Here we used a mammalian membrane-tethered screening system (ECSTASY) to...
3.
Cheng K, Tseng C, Chen I, Huang B, Liu H, Ho K, et al.
Pharmacol Res
. 2022 Feb;
177:106115.
PMID: 35124207
The bidirectional interaction between carcinogens and gut microbiota that contributes to colorectal cancer is complicated. Reactivation of carcinogen metabolites by microbial β-glucuronidase (βG) in the gut potentially plays an important...
4.
Cheng K, Tseng C, Tzeng C, Leu Y, Cheng T, Wang J, et al.
Pharmacol Res
. 2018 Nov;
139:41-49.
PMID: 30391354
Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is...
5.
Burnouf P, Leu Y, Su Y, Wu K, Lin W, Roffler S
Nat Commun
. 2018 May;
9(1):1843.
PMID: 29748577
Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which responds to environmental conditions to alternate between a lipid-soluble...
6.
Cheng K, Tseng C, Yang C, Tzeng C, Cheng T, Leu Y, et al.
J Med Chem
. 2017 Nov;
60(22):9222-9238.
PMID: 29120626
The direct inhibition of bacterial β-glucuronidase (βG) activity is expected to reduce the reactivation of glucuronide-conjugated drugs in the intestine, thereby reducing drug toxicity. In this study, we report on...
7.
Prijovich Z, Burnouf P, Chou H, Huang P, Chen K, Cheng T, et al.
Mol Pharm
. 2016 Jan;
13(4):1242-50.
PMID: 26824303
Major limitations of camptothecin anticancer drugs (toxicity, nonselectivity, water insolubility, inactivation by human serum albumin) may be improved by creating glucuronide prodrugs that rely on beta-glucuronidase for their activation. We...
8.
Cheng T, Chuang K, Roffler S, Cheng K, Leu Y, Chuang C, et al.
ScientificWorldJournal
. 2015 Apr;
2015:740815.
PMID: 25839056
Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinal E. coli β-glucuronidase (eβG) has been considered pivotal...
9.
Chen C, Hsieh Y, Prijovich Z, Chuang H, Chen K, Lu W, et al.
Protein Eng Des Sel
. 2012 Jun;
25(7):367-75.
PMID: 22691701
We describe an adjustable membrane-tethered/soluble protein screening methodology termed ECSTASY (enzyme cleavable surface tethered all-purpose screening system) which combines the power of high-throughput fluorescence-activated cell sorting of membrane-tethered proteins with...
10.
Chen K, Wu S, Leu Y, Prijovich Z, Chen B, Wang H, et al.
Bioconjug Chem
. 2011 Mar;
22(5):938-48.
PMID: 21443266
Antibody-directed enzyme prodrug therapy (ADEPT) utilizing β-glucuronidase is a promising method to enhance the therapeutic index of cancer chemotherapy. In this approach, an immunoenzyme (antibody-β-glucuronidase fusion protein) is employed to...