Steve R Roffler
Overview
Explore the profile of Steve R Roffler including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
97
Citations
1784
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Liu Y, Mori T, Ito Y, Kuroki K, Hayashi S, Kohda D, et al.
J Control Release
. 2025 Feb;
380:396-403.
PMID: 39921032
Polyethylene glycol (PEG) is widely used as a standard stealth polymer, although the induction of anti-PEG antibodies and consequent effects have drawn attention in recent years. To date, several anti-PEG...
2.
Ho K, Liu Y, Huang B, Hong S, Yang S, Liao T, et al.
Int J Biol Macromol
. 2025 Jan;
300:140138.
PMID: 39842595
Glycosidic switch liposome (GSL) technology efficiently encapsulates and stabilizes potent anticancer drugs in liposomes using a reversible glucuronide ester. Enzymatic hydrolysis of the glucuronide switch in target cell lysosomes produces...
3.
Meng J, Dong Z, Chen Y, Lin M, Liu Y, Roffler S, et al.
ACS Nano
. 2025 Jan;
19(1):307-321.
PMID: 39749925
The blood-brain barrier (BBB) remains a major obstacle for effective delivery of therapeutics to treat central nervous system (CNS) disorders. Although transferrin receptor (TfR)-mediated transcytosis is widely employed for brain...
4.
Liu Y, Liao T, Ho K, Liu E, Huang B, Hong S, et al.
Biomater Res
. 2024 Dec;
28:0112.
PMID: 39665081
The presence of anti-polyethylene glycol (anti-PEG) antibodies can hinder the therapeutic efficacy of PEGylated drugs. With the widespread use of a PEGylated coronavirus disease 2019 (COVID-19) messenger RNA vaccine (Comirnaty),...
5.
Chen B, Chen E, Lin Y, Tran T, Turjeman K, Yang S, et al.
ACS Nano
. 2024 Aug;
18(33):22122-22138.
PMID: 39119697
Binding of anti-PEG antibodies to poly(ethylene glycol) (PEG) on the surface of PEGylated liposomal doxorubicin (PLD) and in rats can activate complement and cause the rapid release of doxorubicin from...
6.
Tseng Y, Lin H, Lin S, Chen B, Vo T, Yang S, et al.
J Control Release
. 2024 Feb;
369:179-198.
PMID: 38368947
Engineering human enzymes for therapeutic applications is attractive but introducing new amino acids may adversely affect enzyme stability and immunogenicity. Here we used a mammalian membrane-tethered screening system (ECSTASY) to...
7.
Tran T, Roffler S
Curr Opin Biotechnol
. 2023 Oct;
84:103010.
PMID: 37852029
The corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these...
8.
Chen W, Chang D, Chen B, Lin Y, Barenholz Y, Roffler S
ACS Nano
. 2023 Mar;
17(6):5757-5772.
PMID: 36926834
Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension, and death in the most severe cases. Because many normal...
9.
Lin Y, Chen B, Tran T, Chang T, Al-Qaisi T, Roffler S
J Control Release
. 2023 Jan;
354:354-367.
PMID: 36641121
Methoxy polyethylene glycol (mPEG) is attached to many proteins, peptides, nucleic acids and nanomedicines to improve their biocompatibility. Antibodies that bind PEG are present in many individuals and can be...
10.
Sahoo B, Lin Y, Tu C, Lin C, Liao W, Li F, et al.
Haematologica
. 2022 Aug;
108(5):1284-1299.
PMID: 36005562
A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal is the...