Younes Mokrab
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Explore the profile of Younes Mokrab including associated specialties, affiliations and a list of published articles.
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31
Citations
4345
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Recent Articles
1.
Chekroun I, Shenbagam S, Almarri M, Mokrab Y, Uddin M, Alkhnbashi O, et al.
Nat Genet
. 2025 Feb;
57(3):505-514.
PMID: 39901015
The Greater Middle East (GME) represents a concentrated region of unparalleled genetic diversity, characterized by an abundance of distinct alleles, founder mutations and extensive autozygosity driven by high consanguinity rates....
2.
Aamer W, Al-Maraghi A, Syed N, Devadoss Gandhi G, Aliyev E, Al-Kurbi A, et al.
Genome Med
. 2024 Apr;
16(1):46.
PMID: 38584274
Background: Genome sequencing of large biobanks from under-represented ancestries provides a valuable resource for the interrogation of Mendelian disease burden at world population level, complementing small-scale familial studies. Methods: Here,...
3.
Abdi M, Aliyev E, Trost B, Kohailan M, Aamer W, Syed N, et al.
Genome Med
. 2023 Oct;
15(1):81.
PMID: 37805537
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social and communication skills, restricted interests, and repetitive behaviors. The prevalence of ASD among children in Qatar was...
4.
Anwardeen N, Diboun I, Mokrab Y, Althani A, Elrayess M
BMC Bioinformatics
. 2023 Jun;
24(1):250.
PMID: 37322419
Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and...
5.
Devadoss Gandhi G, Aamer W, Krishnamoorthy N, Syed N, Aliyev E, Al-Maraghi A, et al.
J Transl Med
. 2022 Nov;
20(1):502.
PMID: 36329474
Background: The genetic architecture underlying Familial Hypercholesterolemia (FH) in Middle Eastern Arabs is yet to be fully described, and approaches to assess this from population-wide biobanks are important for public...
6.
Janahi M, Aksman L, Schott J, Mokrab Y, Altmann A
Elife
. 2022 Aug;
11.
PMID: 35938915
Nomograms are important clinical tools applied widely in both developing and aging populations. They are generally constructed as normative models identifying cases as outliers to a distribution of healthy controls....
7.
Noyes M, Harvey W, Porubsky D, Sulovari A, Li R, Rose N, et al.
Am J Hum Genet
. 2022 Mar;
109(4):631-646.
PMID: 35290762
Studies of de novo mutation (DNM) have typically excluded some of the most repetitive and complex regions of the genome because these regions cannot be unambiguously mapped with short-read sequencing...
8.
Saad M, Mokrab Y, Halabi N, Shan J, Razali R, Kunji K, et al.
Lancet Oncol
. 2022 Feb;
23(3):341-352.
PMID: 35150601
Background: Disparities in the genetic risk of cancer among various ancestry groups and populations remain poorly defined. This challenge is even more acute for Middle Eastern populations, where the paucity...
9.
Mbarek H, Devadoss Gandhi G, Selvaraj S, Al-Muftah W, Badji R, Al-Sarraj Y, et al.
Hum Mutat
. 2022 Feb;
43(4):499-510.
PMID: 35112413
Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we...
10.
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Razali R, Rodriguez-Flores J, Ghorbani M, Naeem H, Aamer W, Aliyev E, et al.
Nat Commun
. 2021 Oct;
12(1):5929.
PMID: 34642339
Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic...