Younes Mokrab
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Explore the profile of Younes Mokrab including associated specialties, affiliations and a list of published articles.
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31
Citations
4345
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Recent Articles
11.
Sayaman R, Saad M, Thorsson V, Hu D, Hendrickx W, Roelands J, et al.
Immunity
. 2021 Feb;
54(2):367-386.e8.
PMID: 33567262
Understanding the contribution of the host's genetic background to cancer immunity may lead to improved stratification for immunotherapy and to the identification of novel therapeutic targets. We investigated the effect...
12.
Shan J, Chouchane A, Mokrab Y, Saad M, Boujassoum S, Sayaman R, et al.
Front Oncol
. 2020 Jan;
9:1328.
PMID: 31921621
Triple-negative breast cancer (TNBC) accounts for ~15-20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand...
13.
Sastry K, Naeem H, Mokrab Y, Chouchane A
Oxid Med Cell Longev
. 2019 Dec;
2019:2841814.
PMID: 31871544
Oxidative stress is known to induce melanocyte death, but the underlying mechanisms are incompletely understood. To identify oxidative stress-induced global gene expression changes in melanocytes, we treated PIG1 melanocytes with...
14.
Thorsson V, Gibbs D, Brown S, Wolf D, Bortone D, Yang T, et al.
Immunity
. 2019 Aug;
51(2):411-412.
PMID: 31433971
No abstract available.
15.
Silcock L, Almabrazi H, Mokrab Y, Jithesh P, Al-Hashmi M, James N, et al.
J Transl Med
. 2019 Apr;
17(1):112.
PMID: 30953523
Background: Monoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as the expression of...
16.
Thorsson V, Gibbs D, Brown S, Wolf D, Bortone D, Yang T, et al.
Immunity
. 2018 Apr;
48(4):812-830.e14.
PMID: 29628290
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound...
17.
Hendrickx W, Simeone I, Anjum S, Mokrab Y, Bertucci F, Finetti P, et al.
Oncoimmunology
. 2017 Mar;
6(2):e1253654.
PMID: 28344865
Cancer immunotherapy is revolutionizing the clinical management of several tumors, but has demonstrated limited activity in breast cancer. The development of more effective treatments is hindered by incomplete knowledge of...
18.
Marshall C, Howrigan D, Merico D, Thiruvahindrapuram B, Wu W, Greer D, et al.
Nat Genet
. 2016 Nov;
49(1):27-35.
PMID: 27869829
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited...
19.
Randolph A, Mokrab Y, Bennett A, Sansom M, Ramsey I
Elife
. 2016 Aug;
5.
PMID: 27572256
The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic 'aqueous' H conductance (G). Mutation of a highly conserved 'gating charge' residue in the...
20.
de Jong S, Vidler L, Mokrab Y, Collier D, Breen G
J Psychopharmacol
. 2016 Jun;
30(8):826-30.
PMID: 27302942
Genome-wide association studies (GWAS) have identified thousands of novel genetic associations for complex genetic disorders, leading to the identification of potential pharmacological targets for novel drug development. In schizophrenia, 108...