Yoko Akazawa-Ogawa
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Explore the profile of Yoko Akazawa-Ogawa including associated specialties, affiliations and a list of published articles.
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18
Citations
168
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Recent Articles
11.
Akazawa-Ogawa Y, Nagai H, Hagihara Y
Biophys Rev
. 2017 Dec;
10(2):255-258.
PMID: 29256117
The antibody is one of the most well-studied multi-domain proteins because of its abundance and physiological importance. In this article, we describe the effect of the complex, multi-domain structure of...
12.
Saito Y, Akazawa-Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, et al.
Sci Rep
. 2016 Jul;
6:30793.
PMID: 27470541
Parkinson's disease (PD) is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1, the product of the causative gene of a familial form...
13.
Noda S, So M, Adachi M, Kardos J, Akazawa-Ogawa Y, Hagihara Y, et al.
Biochemistry
. 2016 Jun;
55(28):3937-48.
PMID: 27345358
Ultrasonication is considered one of the most effective agitations for inducing the spontaneous formation of amyloid fibrils. When we induced the ultrasonication-dependent fibrillation of β2-microglobulin and insulin monitored by amyloid-specific...
14.
Akazawa-Ogawa Y, Uegaki K, Hagihara Y
J Biochem
. 2015 Aug;
159(1):111-21.
PMID: 26289739
Camelid-derived single domain VHH antibodies are highly heat resistant, and the mechanism of heat-induced VHH denaturation predominantly relies on the chemical modification of amino acids. Although chemical modification of disulfide...
15.
Ando M, Horie M, Akazawa-Ogawa Y, Hagihara Y, Murase N, Shigeri Y
Biosci Biotechnol Biochem
. 2015 Jul;
80(1):210-3.
PMID: 26214259
CdSe quantum dots (QDs) are potential fluorescent reagents, but leakage of Cd and Se often induces cytotoxicity. Here we prepared CdSe-based QDs with glass to reduce their leakage and examined...
16.
Yagi H, Mizuno A, So M, Hirano M, Adachi M, Akazawa-Ogawa Y, et al.
Biochim Biophys Acta
. 2014 Dec;
1854(3):209-17.
PMID: 25528988
Ultrasonication can be used to break the supersaturation of α-synuclein, a protein associated with Parkinson's disease, at pH7.4 above the critical concentration of fibrillation, thereby inducing the formation of amyloid...
17.
Akazawa-Ogawa Y, Shichiri M, Nishio K, Yoshida Y, Niki E, Hagihara Y
Free Radic Biol Med
. 2014 Dec;
79:164-75.
PMID: 25499849
Linoleates are required for normal mammalian health and development, but they are also prone to oxidation, resulting in biologically active metabolites such as hydroxyoctadecadienoic acids (HODEs). To investigate the biological...
18.
Akazawa-Ogawa Y, Takashima M, Lee Y, Ikegami T, Goto Y, Uegaki K, et al.
J Biol Chem
. 2014 Apr;
289(22):15666-79.
PMID: 24739391
The variable domain of camelid heavy chain antibody (VHH) is highly heat-resistant and is therefore ideal for many applications. Although understanding the process of heat-induced irreversible denaturation is essential to...